Used 2021 Lexus RX 350 AWD for SaleNationwide
161 vehicles found
Shop with transparent pricing.
Only show listings that include dealer fees- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Eminent White Pearl
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 8-Speed Automatic
- Mileage:
- 62,983
- Stock #:
- B20898A
- VIN:
- 2T2AZMDAXMC260286
Price drop
-$1,651
2021 Lexus RX
350 AWD
62,983 mi
Vancouver, WA
Great Deal
$33,499
$31,848
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Eminent White Pearl
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- BIRCH
- Transmission:
- 8-Speed Automatic
- Mileage:
- 55,234
- Stock #:
- 05600
- VIN:
- 2T2HZMDA6MC266844
Price drop
-$8,553
2021 Lexus RX
350 AWD
55,234 mi
Bellingham, WA
Good Deal
$46,248
$37,695
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- White
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 66,998
- Stock #:
- XR052385
- VIN:
- JTJHZMDA4M2052385
2021 Lexus RX
350 AWD
66,998 mi
San Juan, TX
Great Deal
$34,020
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Black (Obsidian)
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Birch
- Transmission:
- 8-Speed Automatic
- Mileage:
- 47,017
- Stock #:
- MC277902
- VIN:
- 2T2HZMDA5MC277902
New arrival
2021 Lexus RX
350 AWD
47,017 mi
Mt Laurel, NJ
Fair Deal
$37,238
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Silver
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 8-Speed Automatic
- Mileage:
- 66,530
- Stock #:
- Q02536A
- VIN:
- 2T2HZMDA9MC258494
Price drop
-$1,023
2021 Lexus RX
350 AWD
66,530 mi
Westborough, MA
Good Deal
$35,995
$34,972
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Black (Caviar)
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 8-Speed Automatic
- Mileage:
- 53,762
- Stock #:
- T04340LC
- VIN:
- 2T2JZMDA2MC292763
Price drop
-$1,013
2021 Lexus RX
350 AWD
53,762 mi
Temecula, CA
Good Deal
$37,010
$36,119
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Eminent White Pearl
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (Tan)
- Transmission:
- 8-Speed Automatic
- Mileage:
- 92,809
- VIN:
- JTJHZMDAXM2054285
New arrival
2021 Lexus RX
350 AWD
92,809 mi
Springdale, AR
Good Deal
$31,888
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Mica
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black Leather
- Transmission:
- Automatic
- Mileage:
- 40,545
- Stock #:
- P12304
- VIN:
- 2T2AZMDAXMC282384
2021 Lexus RX
350 AWD
40,545 mi
St Louis, MO
Good Deal
$37,528
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- White Pearl
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- White (Parchment)
- Transmission:
- 8-Speed Automatic
- Mileage:
- 46,013
- Stock #:
- FP-8099
- VIN:
- 2T2HZMDA0MC290458
New arrival
2021 Lexus RX
350 AWD
46,013 mi
Allen, TX
Fair Deal
$39,116
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Gray Pearl
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Birch
- Transmission:
- 8-Speed Automatic
- Mileage:
- 112,849
- Stock #:
- LL4339A
- VIN:
- 2T2HZMDAXMC284148
Price drop
-$600
2021 Lexus RX
350 AWD
112,849 mi
State College, PA
Great Deal
$27,978
$27,378
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- White
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Gray
- Transmission:
- Automatic
- Mileage:
- 93,010
- Stock #:
- 62N00280B
- VIN:
- 2T2HZMDAXMC283596
2021 Lexus RX
350 AWD
93,010 mi
Smithfield, RI
Good Deal
$30,324
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Silver
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (Beige)
- Transmission:
- Automatic
- Mileage:
- 35,923
- Stock #:
- 267832A
- VIN:
- 2T2HZMDAXMC298163
New arrival
2021 Lexus RX
350 AWD
35,923 mi
Virginia Beach, VA
Good Deal
$39,498
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Black (Obsidian)
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Birch
- Transmission:
- 8-Speed Automatic
- Mileage:
- 48,353
- Stock #:
- LL4340A
- VIN:
- 2T2HZMDAXMC290239
2021 Lexus RX
350 AWD
48,353 mi
State College, PA
Good Deal
$37,378
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Black (Caviar)
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 8-Speed Automatic
- Mileage:
- 70,532
- Stock #:
- 1248P
- VIN:
- 2T2HZMDA3MC275226
2021 Lexus RX
350 AWD
70,532 mi
Denville, NJ
Great Deal
$30,694
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Black (Caviar)
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- White (Parchment)
- Transmission:
- 8-Speed Automatic
- Mileage:
- 61,313
- Stock #:
- 26432A
- VIN:
- 2T2HZMDA1MC303508
New arrival
2021 Lexus RX
350 AWD
61,313 mi
Warrensburg, NY
Good Deal
$35,302
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Matador Red Mica
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- White (Parchment)
- Transmission:
- 8-Speed Automatic
- Mileage:
- 50,172
- Stock #:
- 260613A
- VIN:
- 2T2HZMDA1MC270820
2021 Lexus RX
350 AWD
50,172 mi
Fort Pierce, FL
Good Deal
$36,847
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Black (Obsidian)
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Glazed Caramel
- Transmission:
- 8-Speed Automatic
- Mileage:
- 66,230
- Stock #:
- A2104
- VIN:
- 2T2HZMDA9MC274405
New arrival
2021 Lexus RX
350 AWD
66,230 mi
Whippany, NJ
Fair Deal
$35,098
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Black (Obsidian)
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 8-Speed Automatic
- Mileage:
- 44,889
- Stock #:
- NX10378
- VIN:
- 2T2HZMDA8MC307779
2021 Lexus RX
350 AWD
44,889 mi
Eau Claire, WI
Good Deal
$36,821
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Black (Caviar)
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Birch
- Transmission:
- 8-Speed Automatic
- Mileage:
- 99,032
- Stock #:
- 260218A
- VIN:
- 2T2HZMDA9MC273318
Price drop
-$682
2021 Lexus RX
350 AWD
99,032 mi
Beachwood, OH
Good Deal
$31,608
$30,926
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Black (Caviar)
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Glazed Caramel
- Transmission:
- 8-Speed Automatic
- Mileage:
- 30,089
- Stock #:
- IQU1105P
- VIN:
- 2T2HZMDA5MC270867
Price drop
-$875
2021 Lexus RX
350 AWD
30,089 mi
Bayside, NY
Good Deal
$38,045
$37,170
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Black
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Transmission:
- 8-Speed Automatic
- Mileage:
- 119,567
- Stock #:
- 258251
- VIN:
- 2T2HZMDA5MC258251
2021 Lexus RX
350 AWD
119,567 mi
Warminster, PA
Good Deal
$27,876
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Gray Pearl
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- White (Parchment)
- Transmission:
- 8-Speed Automatic
- Mileage:
- 148,908
- Stock #:
- MC292889
- VIN:
- 2T2HZMDA4MC292889
Price drop
-$547
2021 Lexus RX
350 AWD
148,908 mi
Brandon, MS
Great Deal
$25,110
$24,563
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Eminent White Pearl
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Birch
- Transmission:
- 8-Speed Automatic
- Mileage:
- 56,512
- Stock #:
- 30149A
- VIN:
- 2T2AZMDA5MC265170
2021 Lexus RX
350 AWD
56,512 mi
Brookfield, WI
Good Deal
$38,215
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Gray
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 45,378
- Stock #:
- T5096A
- VIN:
- 2T2HZMDA6MC269050
2021 Lexus RX
350 AWD
45,378 mi
Towson, MD
Good Deal
$36,799
5.0 Overall rating
Filter by rating
Michael B
Reviewed a 2021 Lexus 350 AWD on Sep 18, 2025
Premium package with LTA, SCS, heating/ventilation seating, pre-collision detection, etc.
Is this review helpful?
FAQs
How much does the Lexus RX 350 AWD cost?
The average Lexus RX 350 AWD costs about $35,374.52. The average price has decreased by -1.3% since last year. The 2061 for sale on CarGurus range from $2,650 to $80,198 in price.
How many Lexus RX 350 AWD vehicles have no reported accidents or damage?
1268 out of 2061 for sale have no reported accidents or damage.
What is the fuel economy of the Lexus RX 350 AWD?
Depending on the engine and options, the Lexus RX 350 AWD gets between 19 and 24 MPG/MPGe.
What fuel types are available?
Gasoline engines are available.
*CarGurus meticulously monitors the prices of millions of pre-owned vehicle listings, offering users precise and up-to-date market insights. Historical pricing data excludes any additional dealer fees as of May 3, 2026.
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