Used 2021 Lexus RX Hybrid 450h AWD for SaleNationwide
55 vehicles found
Shop with transparent pricing.
Only show listings that include dealer fees- Year:
- 2021
- Make:
- Lexus
- Model:
- RX Hybrid
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 3.5L V6 Hybrid
- Exterior color:
- White Pearl
- Combined gas mileage:
- 30 MPG
- Fuel type:
- Hybrid
- Interior color:
- Birch
- Transmission:
- Continuously Variable Transmission
- Mileage:
- 74,813
- Stock #:
- GU1026
- VIN:
- 2T2HGMDA3MC063626
Price drop
-$1,275
2021 Lexus RX Hybrid
450h AWD
74,813 mi
Brooklyn, NY
Great Deal
$34,163
$33,063
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX Hybrid
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 3.5L V6 Hybrid
- Exterior color:
- Eminent White Pearl
- Combined gas mileage:
- 30 MPG
- Fuel type:
- Hybrid
- Interior color:
- Birch
- Transmission:
- Continuously Variable Transmission
- Mileage:
- 75,046
- Stock #:
- P9643
- VIN:
- 2T2HGMDA2MC062984
Price drop
-$750
2021 Lexus RX Hybrid
450h AWD
75,046 mi
Albany, NY
Great Deal
$35,675
$34,925
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX Hybrid
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 3.5L V6 Hybrid
- Exterior color:
- White
- Combined gas mileage:
- 30 MPG
- Fuel type:
- Hybrid
- Interior color:
- Black
- Transmission:
- Continuously Variable Transmission
- Mileage:
- 69,094
- Stock #:
- T0514
- VIN:
- 2T2HGMDA8MC069633
Price drop
-$2,000
2021 Lexus RX Hybrid
450h AWD
69,094 mi
Fort Collins, CO
Good Deal
$38,990
$36,990
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX Hybrid
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 3.5L V6 Hybrid
- Exterior color:
- White
- Combined gas mileage:
- 30 MPG
- Fuel type:
- Hybrid
- Transmission:
- Continuously Variable Transmission
- Mileage:
- 61,260
- Stock #:
- 266079A
- VIN:
- 2T2HGMDA3MC066106
Price drop
-$1,400
2021 Lexus RX Hybrid
450h AWD
61,260 mi
Fort Collins, CO
Good Deal
$39,990
$38,590
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX Hybrid
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 3.5L V6 Hybrid
- Exterior color:
- Eminent White Pearl
- Combined gas mileage:
- 30 MPG
- Fuel type:
- Hybrid
- Interior color:
- White (Parchment)
- Transmission:
- Continuously Variable Transmission
- Mileage:
- 43,146
- Stock #:
- 4615321
- VIN:
- 2T2JGMDA3MC058346
2021 Lexus RX Hybrid
450h AWD
43,146 mi
Philadelphia, PA
Fair Deal
$45,485
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX Hybrid
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 3.5L V6 Hybrid
- Exterior color:
- Eminent White Pearl
- Combined gas mileage:
- 30 MPG
- Fuel type:
- Hybrid
- Interior color:
- White (Parchment)
- Transmission:
- Continuously Variable Transmission
- Mileage:
- 109,376
- Stock #:
- AT045174B
- VIN:
- 2T2HGMDA3MC064288
2021 Lexus RX Hybrid
450h AWD
109,376 mi
Cleveland, OH
Good Deal
$33,130
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX Hybrid
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 3.5L V6 Hybrid
- Exterior color:
- Atomic Silver
- Combined gas mileage:
- 30 MPG
- Fuel type:
- Hybrid
- Interior color:
- Black
- Transmission:
- Continuously Variable Transmission
- Mileage:
- 49,253
- Stock #:
- G50116
- VIN:
- 2T2HGMDAXMC067902
2021 Lexus RX Hybrid
450h AWD
49,253 mi
Savannah, TN
Fair Deal
$42,257
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX Hybrid
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 3.5L V6 Hybrid
- Exterior color:
- White Pearl
- Combined gas mileage:
- 30 MPG
- Fuel type:
- Hybrid
- Interior color:
- Black
- Transmission:
- Continuously Variable Transmission
- Mileage:
- 97,832
- Stock #:
- MC059071A
- VIN:
- 2T2HGMDA8MC059071
2021 Lexus RX Hybrid
450h AWD
97,832 mi
Corona, CA
Fair Deal
$33,811
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX Hybrid
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 3.5L V6 Hybrid
- Exterior color:
- Gray Pearl
- Combined gas mileage:
- 30 MPG
- Fuel type:
- Hybrid
- Interior color:
- Birch
- Transmission:
- Continuously Variable Transmission
- Mileage:
- 77,981
- Stock #:
- 14761
- VIN:
- 2T2HGMDA9MC058415
Photos coming soon
2021 Lexus RX Hybrid
450h AWD
77,981 mi
Tigard, OR
Fair Deal
$39,245
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX Hybrid
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 3.5L V6 Hybrid
- Exterior color:
- Black (Caviar)
- Combined gas mileage:
- 30 MPG
- Fuel type:
- Hybrid
- Interior color:
- White (Parchment)
- Transmission:
- Continuously Variable Transmission
- Mileage:
- 65,998
- Stock #:
- KT2914
- VIN:
- 2T2HGMDA8MC071110
2021 Lexus RX Hybrid
450h AWD
65,998 mi
Indio, CA
Good Deal
$37,777
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX Hybrid
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 3.5L V6 Hybrid
- Exterior color:
- White
- Combined gas mileage:
- 30 MPG
- Fuel type:
- Hybrid
- Interior color:
- Brown (Tan)
- Transmission:
- Automatic
- Mileage:
- 52,804
- Stock #:
- CMC068760
- VIN:
- 2T2HGMDAXMC068760
2021 Lexus RX Hybrid
450h AWD
52,804 mi
Englewood, CO
Good Deal
$38,997
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX Hybrid
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 3.5L V6 Hybrid
- Exterior color:
- Atomic Silver
- Combined gas mileage:
- 30 MPG
- Fuel type:
- Hybrid
- Interior color:
- Black
- Transmission:
- Continuously Variable Transmission
- Mileage:
- 71,406
- Stock #:
- C066063CC
- VIN:
- 2T2HGMDA0MC066063
New arrival
2021 Lexus RX Hybrid
450h AWD
71,406 mi
Spokane, WA
Fair Deal
$40,995
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX Hybrid
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 3.5L V6 Hybrid
- Exterior color:
- Atomic Silver
- Combined gas mileage:
- 30 MPG
- Fuel type:
- Hybrid
- Interior color:
- Birch
- Transmission:
- Continuously Variable Transmission
- Mileage:
- 34,888
- Stock #:
- MC062837
- VIN:
- 2T2HGMDA0MC062837
2021 Lexus RX Hybrid
450h AWD
34,888 mi
Parker, CO
Fair Deal
$45,199
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX Hybrid
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 3.5L V6 Hybrid
- Exterior color:
- Mica
- Combined gas mileage:
- 30 MPG
- Fuel type:
- Hybrid
- Interior color:
- Birch
- Transmission:
- Continuously Variable Transmission
- Mileage:
- 100,573
- Stock #:
- A065888
- VIN:
- 2T2HGMDAXMC065888
2021 Lexus RX Hybrid
450h AWD
100,573 mi
Bensenville, IL
Good Deal
$33,278
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX Hybrid
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 3.5L V6 Hybrid
- Exterior color:
- Black (Caviar)
- Combined gas mileage:
- 30 MPG
- Fuel type:
- Hybrid
- Interior color:
- White (Parchment)
- Transmission:
- Continuously Variable Transmission
- Mileage:
- 43,886
- Stock #:
- U071130
- VIN:
- 2T2HGMDA3MC071130
2021 Lexus RX Hybrid
450h AWD
43,886 mi
Butler, NJ
Good Deal
$41,574
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX Hybrid
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 3.5L V6 Hybrid
- Exterior color:
- Black
- Combined gas mileage:
- 30 MPG
- Fuel type:
- Hybrid
- Interior color:
- Black
- Transmission:
- Continuously Variable Transmission
- Mileage:
- 112,590
- Stock #:
- MC060519
- VIN:
- 2T2HGMDA9MC060519
2021 Lexus RX Hybrid
450h AWD
112,590 mi
Broomfield, CO
Fair Deal
$33,474
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX Hybrid
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 3.5L V6 Hybrid
- Exterior color:
- Gray
- Combined gas mileage:
- 30 MPG
- Fuel type:
- Hybrid
- Interior color:
- Brown
- Transmission:
- Continuously Variable Transmission
- Mileage:
- 52,876
- Stock #:
- B100290
- VIN:
- 2T2JGMDA7MC058043
2021 Lexus RX Hybrid
450h AWD
52,876 mi
Elkridge, MD
Fair Deal
$42,794
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX Hybrid
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 3.5L V6 Hybrid
- Exterior color:
- Black (Caviar)
- Combined gas mileage:
- 30 MPG
- Fuel type:
- Hybrid
- Interior color:
- Black
- Transmission:
- Continuously Variable Transmission
- Mileage:
- 51,056
- Stock #:
- U2200475
- VIN:
- 2T2HGMDA9MC065431
2021 Lexus RX Hybrid
450h AWD
51,056 mi
Lowell, MA
Good Deal
$40,429
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX Hybrid
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 3.5L V6 Hybrid
- Exterior color:
- Eminent White Pearl
- Combined gas mileage:
- 30 MPG
- Fuel type:
- Hybrid
- Interior color:
- Black
- Transmission:
- Continuously Variable Transmission
- Mileage:
- 42,540
- Stock #:
- 460822A
- VIN:
- 2T2HGMDA2MC063746
2021 Lexus RX Hybrid
450h AWD
42,540 mi
Cathedral City, CA
Fair Deal
$43,500
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX Hybrid
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 3.5L V6 Hybrid
- Exterior color:
- Silver
- Combined gas mileage:
- 30 MPG
- Fuel type:
- Hybrid
- Interior color:
- Birch
- Transmission:
- Continuously Variable Transmission
- Mileage:
- 80,356
- Stock #:
- M1246
- VIN:
- 2T2HGMDA1MC062815
2021 Lexus RX Hybrid
450h AWD
80,356 mi
Henderson, NV
Good Deal
$36,194
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX Hybrid
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 3.5L V6 Hybrid
- Exterior color:
- Atomic Silver
- Combined gas mileage:
- 30 MPG
- Fuel type:
- Hybrid
- Interior color:
- Birch
- Transmission:
- Automatic
- Mileage:
- 87,379
- Stock #:
- MC059502
- VIN:
- 2T2JGMDA7MC059502
New arrival
2021 Lexus RX Hybrid
450h AWD
87,379 mi
Cerritos, CA
Fair Deal
$37,792
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX Hybrid
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 3.5L V6 Hybrid
- Exterior color:
- White Pearl
- Combined gas mileage:
- 30 MPG
- Fuel type:
- Hybrid
- Interior color:
- Black
- Transmission:
- Continuously Variable Transmission
- Mileage:
- 61,909
- Stock #:
- TMC058104
- VIN:
- 2T2HGMDA3MC058104
2021 Lexus RX Hybrid
450h AWD
61,909 mi
Palm Springs, CA
Fair Deal
$39,873
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX Hybrid
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 3.5L V6 Hybrid
- Exterior color:
- Gray Pearl
- Combined gas mileage:
- 30 MPG
- Fuel type:
- Hybrid
- Interior color:
- Birch
- Transmission:
- Continuously Variable Transmission
- Mileage:
- 80,392
- Stock #:
- P061804
- VIN:
- 2T2HGMDA2MC061804
New arrival
2021 Lexus RX Hybrid
450h AWD
80,392 mi
Portland, OR
Fair Deal
$40,100
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX Hybrid
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 3.5L V6 Hybrid
- Exterior color:
- Silver
- Combined gas mileage:
- 30 MPG
- Fuel type:
- Hybrid
- Interior color:
- Black
- Transmission:
- Continuously Variable Transmission
- Mileage:
- 74,134
- Stock #:
- 54L1339P
- VIN:
- 2T2HGMDA9MC069947
2021 Lexus RX Hybrid
450h AWD
74,134 mi
Wichita, KS
Fair Deal
$40,093
5.0 Overall rating
Filter by rating
David D
Reviewed a 2021 Lexus 450h AWD on Aug 25, 2025
I think it’s the most enjoyable car I’ve ever driven in my 66 years of driving
Is this review helpful?
FAQs
How much does the Lexus RX Hybrid 450h AWD cost?
The average Lexus RX Hybrid 450h AWD costs about $39,473.22. The average price has increased by 1.5% since last year. The 452 for sale on CarGurus range from $4,901 to $53,552 in price.
How many Lexus RX Hybrid 450h AWD vehicles have no reported accidents or damage?
316 out of 452 for sale have no reported accidents or damage.
What is the fuel economy of the Lexus RX Hybrid 450h AWD?
Depending on the engine and options, the Lexus RX Hybrid 450h AWD gets between 29 and 29 MPG/MPGe.
What fuel types are available?
Hybrid engines are available.
*CarGurus meticulously monitors the prices of millions of pre-owned vehicle listings, offering users precise and up-to-date market insights. Historical pricing data excludes any additional dealer fees as of May 3, 2026.
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