Used 2021 Lexus RX Hybrid 450h AWD for SaleNationwide
56 vehicles found
Shop with transparent pricing.
Only show listings that include dealer fees- Year:
- 2021
- Make:
- Lexus
- Model:
- RX Hybrid
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 3.5L V6 Hybrid
- Exterior color:
- White Pearl
- Combined gas mileage:
- 30 MPG
- Fuel type:
- Hybrid
- Interior color:
- White (Parchment)
- Transmission:
- Continuously Variable Transmission
- Mileage:
- 43,146
- Stock #:
- 1177209
- VIN:
- 2T2JGMDA3MC058346
2021 Lexus RX Hybrid
450h AWD
43,146 mi
Glenside, PA
Fair Deal
$42,371
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX Hybrid
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 3.5L V6 Hybrid
- Exterior color:
- Black
- Combined gas mileage:
- 30 MPG
- Fuel type:
- Hybrid
- Transmission:
- Continuously Variable Transmission
- Mileage:
- 69,023
- Stock #:
- 26387
- VIN:
- 2T2HGMDA1MC069134
2021 Lexus RX Hybrid
450h AWD
69,023 mi
Franktown, CO
Good Deal
$37,000
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX Hybrid
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 3.5L V6 Hybrid
- Exterior color:
- Atomic Silver
- Combined gas mileage:
- 30 MPG
- Fuel type:
- Hybrid
- Interior color:
- Black
- Transmission:
- Continuously Variable Transmission
- Mileage:
- 49,274
- Stock #:
- G50116
- VIN:
- 2T2HGMDAXMC067902
2021 Lexus RX Hybrid
450h AWD
49,274 mi
Savannah, TN
Great Deal
$38,909
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX Hybrid
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 3.5L V6 Hybrid
- Exterior color:
- Silver
- Combined gas mileage:
- 30 MPG
- Fuel type:
- Hybrid
- Interior color:
- Birch
- Transmission:
- Continuously Variable Transmission
- Mileage:
- 80,356
- Stock #:
- M1246
- VIN:
- 2T2HGMDA1MC062815
Price drop
-$1,499
2021 Lexus RX Hybrid
450h AWD
80,356 mi
Henderson, NV
Great Deal
$33,995
$32,995
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX Hybrid
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 3.5L V6 Hybrid
- Exterior color:
- Eminent White Pearl
- Combined gas mileage:
- 30 MPG
- Fuel type:
- Hybrid
- Interior color:
- White (Parchment)
- Transmission:
- Continuously Variable Transmission
- Mileage:
- 109,376
- Stock #:
- AT045174B
- VIN:
- 2T2HGMDA3MC064288
2021 Lexus RX Hybrid
450h AWD
109,376 mi
Cleveland, OH
Good Deal
$31,332
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX Hybrid
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 3.5L V6 Hybrid
- Exterior color:
- White
- Combined gas mileage:
- 30 MPG
- Fuel type:
- Hybrid
- Interior color:
- Brown (Tan)
- Transmission:
- Automatic
- Mileage:
- 89,425
- Stock #:
- CMC062996
- VIN:
- 2T2HGMDA9MC062996
2021 Lexus RX Hybrid
450h AWD
89,425 mi
Birmingham, AL
Great Deal
$33,096
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX Hybrid
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 3.5L V6 Hybrid
- Exterior color:
- Atomic Silver
- Combined gas mileage:
- 30 MPG
- Fuel type:
- Hybrid
- Interior color:
- Birch
- Transmission:
- Automatic
- Mileage:
- 87,379
- Stock #:
- MC059502
- VIN:
- 2T2JGMDA7MC059502
2021 Lexus RX Hybrid
450h AWD
87,379 mi
Cerritos, CA
Good Deal
$33,482
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX Hybrid
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 3.5L V6 Hybrid
- Exterior color:
- Nightfall Mica
- Combined gas mileage:
- 30 MPG
- Fuel type:
- Hybrid
- Interior color:
- White (Parchment)
- Transmission:
- Continuously Variable Transmission
- Mileage:
- 71,796
- Stock #:
- MC058056
- VIN:
- 2T2HGMDA7MC058056
New arrival
2021 Lexus RX Hybrid
450h AWD
71,796 mi
Arlington, TX
Fair Deal
$37,722
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX Hybrid
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 3.5L V6 Hybrid
- Exterior color:
- Atomic Silver
- Combined gas mileage:
- 30 MPG
- Fuel type:
- Hybrid
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 70,748
- Stock #:
- MC058146
- VIN:
- 2T2HGMDA8MC058146
New arrival
2021 Lexus RX Hybrid
450h AWD
70,748 mi
Spokane, WA
Good Deal
$38,269
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX Hybrid
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 3.5L V6 Hybrid
- Exterior color:
- Gray
- Combined gas mileage:
- 30 MPG
- Fuel type:
- Hybrid
- Transmission:
- 6-Speed CVT
- Mileage:
- 62,463
- Stock #:
- TMC064449
- VIN:
- 2T2HGMDA1MC064449
2021 Lexus RX Hybrid
450h AWD
62,463 mi
Richardson, TX
Fair Deal
$38,967
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX Hybrid
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 3.5L V6 Hybrid
- Exterior color:
- Atomic Silver
- Combined gas mileage:
- 30 MPG
- Fuel type:
- Hybrid
- Interior color:
- White (Parchment)
- Transmission:
- Continuously Variable Transmission
- Mileage:
- 39,165
- Stock #:
- 37067945
- VIN:
- 2T2JGMDA4MC067945
New arrival
2021 Lexus RX Hybrid
450h AWD
39,165 mi
Moorhead, MN
Good Deal
$41,848
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX Hybrid
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 3.5L V6 Hybrid
- Exterior color:
- Atomic Silver
- Combined gas mileage:
- 30 MPG
- Fuel type:
- Hybrid
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 61,881
- Stock #:
- MC059397
- VIN:
- 2T2HGMDA5MC059397
2021 Lexus RX Hybrid
450h AWD
61,881 mi
Sterling, VA
Fair Deal
$39,383
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX Hybrid
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 3.5L V6 Hybrid
- Exterior color:
- Black (Obsidian)
- Combined gas mileage:
- 30 MPG
- Fuel type:
- Hybrid
- Interior color:
- Black
- Transmission:
- Continuously Variable Transmission
- Mileage:
- 102,637
- Stock #:
- MC072051
- VIN:
- 2T2HGMDA1MC072051
Price drop
-$1,509
2021 Lexus RX Hybrid
450h AWD
102,637 mi
Danvers, MA
Great Deal
$32,092
$30,583
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX Hybrid
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 3.5L V6 Hybrid
- Exterior color:
- Black (Caviar)
- Combined gas mileage:
- 30 MPG
- Fuel type:
- Hybrid
- Interior color:
- White (Parchment)
- Transmission:
- Continuously Variable Transmission
- Mileage:
- 65,998
- Stock #:
- KT2914
- VIN:
- 2T2HGMDA8MC071110
Price drop
-$2,078
2021 Lexus RX Hybrid
450h AWD
65,998 mi
Indio, CA
Good Deal
$39,068
$36,990
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX Hybrid
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 3.5L V6 Hybrid
- Exterior color:
- Atomic Silver
- Combined gas mileage:
- 30 MPG
- Fuel type:
- Hybrid
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 95,626
- Stock #:
- MC057215
- VIN:
- 2T2HGMDA7MC057215
2021 Lexus RX Hybrid
450h AWD
95,626 mi
San Jose, CA
Great Deal
$30,766
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX Hybrid
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 3.5L V6 Hybrid
- Exterior color:
- Eminent White Pearl
- Combined gas mileage:
- 30 MPG
- Fuel type:
- Hybrid
- Interior color:
- Black
- Transmission:
- Continuously Variable Transmission
- Mileage:
- 61,911
- Stock #:
- SMC058104
- VIN:
- 2T2HGMDA3MC058104
Price drop
-$1,075
2021 Lexus RX Hybrid
450h AWD
61,911 mi
Palm Springs, CA
Fair Deal
$38,745
$37,670
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX Hybrid
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 3.5L V6 Hybrid
- Exterior color:
- Black (Caviar)
- Combined gas mileage:
- 30 MPG
- Fuel type:
- Hybrid
- Interior color:
- White (Parchment)
- Transmission:
- Continuously Variable Transmission
- Mileage:
- 95,825
- Stock #:
- RP064505
- VIN:
- 2T2HGMDA7MC064505
2021 Lexus RX Hybrid
450h AWD
95,825 mi
Wilmington, DE
Good Deal
$32,777
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX Hybrid
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 3.5L V6 Hybrid
- Exterior color:
- White Pearl
- Combined gas mileage:
- 30 MPG
- Fuel type:
- Hybrid
- Interior color:
- Black
- Transmission:
- Continuously Variable Transmission
- Mileage:
- 97,832
- Stock #:
- MC059071A
- VIN:
- 2T2HGMDA8MC059071
2021 Lexus RX Hybrid
450h AWD
97,832 mi
Corona, CA
Fair Deal
$31,119
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX Hybrid
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 3.5L V6 Hybrid
- Exterior color:
- Nebula Gray Pearl
- Combined gas mileage:
- 30 MPG
- Fuel type:
- Hybrid
- Interior color:
- Black
- Transmission:
- Continuously Variable Transmission
- Mileage:
- 44,940
- Stock #:
- 14569AB
- VIN:
- 2T2HGMDA9MC058835
2021 Lexus RX Hybrid
450h AWD
44,940 mi
Raleigh, NC
Fair Deal
$42,879
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX Hybrid
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 3.5L V6 Hybrid
- Exterior color:
- Black (Obsidian)
- Combined gas mileage:
- 30 MPG
- Fuel type:
- Hybrid
- Interior color:
- Birch
- Transmission:
- Continuously Variable Transmission
- Mileage:
- 45,189
- Stock #:
- K629094B
- VIN:
- 2T2HGMDA1MC068064
New arrival
2021 Lexus RX Hybrid
450h AWD
45,189 mi
Birmingham, AL
Fair Deal
$42,972
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX Hybrid
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 3.5L V6 Hybrid
- Exterior color:
- Mica
- Combined gas mileage:
- 30 MPG
- Fuel type:
- Hybrid
- Interior color:
- Birch
- Transmission:
- Continuously Variable Transmission
- Mileage:
- 100,573
- Stock #:
- A065888
- VIN:
- 2T2HGMDAXMC065888
2021 Lexus RX Hybrid
450h AWD
100,573 mi
Bensenville, IL
Great Deal
$29,773
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX Hybrid
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 3.5L V6 Hybrid
- Exterior color:
- Black (Caviar)
- Combined gas mileage:
- 30 MPG
- Fuel type:
- Hybrid
- Interior color:
- Black
- Transmission:
- Continuously Variable Transmission
- Mileage:
- 84,039
- Stock #:
- 1104084
- VIN:
- 2T2HGMDA8MC071317
New arrival
2021 Lexus RX Hybrid
450h AWD
84,039 mi
Raleigh, NC
Good Deal
$36,498
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX Hybrid
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 3.5L V6 Hybrid
- Exterior color:
- Black (Caviar)
- Combined gas mileage:
- 30 MPG
- Fuel type:
- Hybrid
- Interior color:
- Black
- Transmission:
- Continuously Variable Transmission
- Mileage:
- 86,600
- Stock #:
- 9925741
- VIN:
- 2T2HGMDA4MC063702
2021 Lexus RX Hybrid
450h AWD
86,600 mi
Louisville, KY
Good Deal
$34,898
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX Hybrid
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 3.5L V6 Hybrid
- Exterior color:
- Nebula Gray Pearl
- Combined gas mileage:
- 30 MPG
- Fuel type:
- Hybrid
- Interior color:
- Birch
- Transmission:
- Continuously Variable Transmission
- Mileage:
- 49,838
- Stock #:
- SPJ2035
- VIN:
- 2T2HGMDA8MC061726
2021 Lexus RX Hybrid
450h AWD
49,838 mi
Gilbert, AZ
Good Deal
$40,072
5.0 Overall rating
Filter by rating
David D
Reviewed a 2021 Lexus 450h AWD on Aug 25, 2025
I think it’s the most enjoyable car I’ve ever driven in my 66 years of driving
Is this review helpful?
FAQs
How much does the Lexus RX Hybrid 450h AWD cost?
The average Lexus RX Hybrid 450h AWD costs about $38,394.18. The average price has decreased by -2.1% since last year. The 466 for sale on CarGurus range from $4,800 to $53,998 in price.
How many Lexus RX Hybrid 450h AWD vehicles have no reported accidents or damage?
312 out of 466 for sale have no reported accidents or damage.
What is the fuel economy of the Lexus RX Hybrid 450h AWD?
Depending on the engine and options, the Lexus RX Hybrid 450h AWD gets between 29 and 29 MPG/MPGe.
What fuel types are available?
Hybrid engines are available.
*CarGurus meticulously monitors the prices of millions of pre-owned vehicle listings, offering users precise and up-to-date market insights. Historical pricing data excludes any additional dealer fees as of May 3, 2026.
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