Used 2021 Mercedes-Benz E-Class for SaleNationwide
Shop with transparent pricing.
Only show listings that include dealer fees- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Gray
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 69,655
- Stock #:
- 725821
- VIN:
- WDDZF8EBXLA725821
2020 Mercedes-Benz E-Class
E 350 4MATIC AWD
69,655 mi
$21,189
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Lunar Blue Metallic
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (Macchiato Beige/Black)
- Transmission:
- 9-Speed Automatic
- Mileage:
- 40,155
- Stock #:
- W9168B
- VIN:
- W1KZF8DB2MA978232

2021 Mercedes-Benz E-Class
E 350 RWD
40,155 mi
$28,489
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Iridium Silver Metallic
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Macchiato Beige/Espresso Brown
- Transmission:
- 9-Speed Automatic
- Mileage:
- 55,680
- Stock #:
- M23887B
- VIN:
- WDDZF8EB6LA744401

-$3,600
2020 Mercedes-Benz E-Class
E 350 4MATIC AWD
55,680 mi
$31,097
$27,497
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L V6
- Exterior color:
- Gray
- Combined gas mileage:
- 24 MPG
- Fuel type:
- Gasoline
- Transmission:
- Automatic
- Mileage:
- 41,863
- Stock #:
- 802080
- VIN:
- W1KZF6JB4LA802080

2020 Mercedes-Benz E-Class
E 450 4MATIC AWD
41,863 mi
$31,620
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Black
- Combined gas mileage:
- 27 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (Macchiato Beige Black)
- Transmission:
- 9-Speed Automatic
- Mileage:
- 16,871
- Stock #:
- I094328A
- VIN:
- W1KZF8DB6NB050550

-$3,907
2022 Mercedes-Benz E-Class
E 350 RWD
16,871 mi
$32,089
$30,267
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Lunar Blue Metallic
- Combined gas mileage:
- 27 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (Macchiato Beige/Black)
- Transmission:
- Automatic
- Mileage:
- 36,536
- Stock #:
- PP4695
- VIN:
- WDDZF8DB4LA712595

2020 Mercedes-Benz E-Class
E 350 Sedan RWD
36,536 mi
$27,499
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Black
- Combined gas mileage:
- 27 MPG
- Fuel type:
- Gasoline
- Transmission:
- 9-Speed Automatic
- Mileage:
- 37,718
- Stock #:
- H26119A
- VIN:
- W1KZF8DB6NB064013

2022 Mercedes-Benz E-Class
E 350 RWD
37,718 mi
$34,626
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Black
- Combined gas mileage:
- 27 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 54,204
- Stock #:
- K33480A
- VIN:
- W1KZF8DB2NB077499

2022 Mercedes-Benz E-Class
E 350 RWD
54,204 mi
$27,579
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Coupe
- Doors:
- 2 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Black
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 21,123
- Stock #:
- 7143Q
- VIN:
- W1K1J5KB9MF162926

2021 Mercedes-Benz E-Class
E 450 4MATIC Coupe AWD
21,123 mi
$40,901
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Black
- Combined gas mileage:
- 24 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 34,579
- Stock #:
- G5947A
- VIN:
- WDDZF6BB3LA726897

-$2,986
2020 Mercedes-Benz E-Class
AMG E 53 Sedan 4MATIC
34,579 mi
$45,189
$42,581
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Nautical Blue Metallic
- Combined gas mileage:
- 27 MPG
- Fuel type:
- Gasoline
- Interior color:
- Neva White Magma Grey
- Transmission:
- 9-Speed Automatic
- Mileage:
- 50,847
- Stock #:
- C6793A
- VIN:
- W1KZF8DBXNB085026

2022 Mercedes-Benz E-Class
E 350 RWD
50,847 mi
$29,989
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Obsidian Black Metallic
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Gray (Titanium Grey/Black)
- Transmission:
- 9-Speed Automatic
- Mileage:
- 55,276
- Stock #:
- 270336AR
- VIN:
- W1KZF6BB3MA993233

2021 Mercedes-Benz E-Class
AMG 53 E Sedan 4MATIC
55,276 mi
$43,222
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 255 hp 2L I4
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Transmission:
- 9-Speed Automatic
- Mileage:
- 57,201
- Stock #:
- 908978K
- VIN:
- W1KZF8DB1MA908978

2021 Mercedes-Benz E-Class
E 350 RWD
57,201 mi
$25,878
CarGurus Analysis:
2021 Mercedes-Benz E-Class
With 833 currently listed for sale and an average price of $36,472, 35.7% of 2021 Mercedes-Benz E-Class models for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2021 Mercedes-Benz E-Class 4.7 / 5 stars and CarGurus experts gave it an 8.33 / 10.
74.8% of 2021 E-Class models on CarGurus are accident free.
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Polar White
- Combined gas mileage:
- 27 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 116,706
- Stock #:
- T0421A
- VIN:
- WDDZF8DB9LA720627

-$3,391
2020 Mercedes-Benz E-Class
E 350 Sedan RWD
116,706 mi
$23,194
$19,803
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Black
- Combined gas mileage:
- 27 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 61,417
- Stock #:
- LA749866B
- VIN:
- WDDZF8DB7LA749866

2020 Mercedes-Benz E-Class
E 350 Sedan RWD
61,417 mi
$24,429
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Polar White
- Combined gas mileage:
- 27 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (Macchiato Beige/Black)
- Transmission:
- Automatic
- Mileage:
- 38,323
- Stock #:
- NB056338
- VIN:
- W1KZF8DB5NB056338

-$1,000
2022 Mercedes-Benz E-Class
E 350 RWD
38,323 mi
$31,994
$30,994
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Polar White
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (Macchiato Beige/Black)
- Transmission:
- 9-Speed Automatic
- Mileage:
- 35,534
- Stock #:
- SD595A
- VIN:
- W1KZF5KB5NB084240

2022 Mercedes-Benz E-Class
E 450 4MATIC Sedan AWD
35,534 mi
$44,744
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- White
- Combined gas mileage:
- 27 MPG
- Fuel type:
- Gasoline
- Interior color:
- Gray
- Transmission:
- Automatic
- Mileage:
- 36,791
- Stock #:
- 847327
- VIN:
- W1KZF8DB7LA847327

2020 Mercedes-Benz E-Class
E 350 Sedan RWD
36,791 mi
$23,264
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Obsidian Black Metallic
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (Macchiato Beige/Black)
- Transmission:
- 9-Speed Automatic
- Mileage:
- 82,197
- Stock #:
- M1498
- VIN:
- WDDZF8EB0LA699598

2020 Mercedes-Benz E-Class
E 350 4MATIC AWD
82,197 mi
$23,993
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 255 hp 2L I4
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Mileage:
- 27,009
- Stock #:
- N0901085A
- VIN:
- W1KZF8EB3NB044767

-$933
2022 Mercedes-Benz E-Class
E 350 4MATIC
27,009 mi
$35,427
$34,494
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Coupe
- Doors:
- 2 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L V6
- Exterior color:
- Polar White
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 41,107
- Stock #:
- LF133001
- VIN:
- W1K1J6JB2LF133001

2020 Mercedes-Benz E-Class
E 450 4MATIC Coupe AWD
41,107 mi
$31,657
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- designo Diamond White Metallic
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (Macchiato Beige/Blac)
- Transmission:
- Automatic
- Mileage:
- 26,476
- Stock #:
- 707729
- VIN:
- WDDZF8EB9LA707729

2020 Mercedes-Benz E-Class
E 350 4MATIC AWD
26,476 mi
$26,595
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Coupe
- Doors:
- 2 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L V6
- Exterior color:
- Polar White
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 65,274
- Stock #:
- 134490A
- VIN:
- W1K1J6JB4LF134490

2020 Mercedes-Benz E-Class
E 450 4MATIC Coupe AWD
65,274 mi
$29,844
CarGurus Analysis: 2021 Mercedes-Benz E-Class
overall

Summary
With 833 currently listed for sale and an average price of $36,472, 35.7% of 2021 Mercedes-Benz E-Class models for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2021 Mercedes-Benz E-Class 4.7 / 5 stars and CarGurus experts gave it an 8.33 / 10.
74.8% of 2021 E-Class models on CarGurus are accident free.
Why it stands out
The 2021 Mercedes-Benz E-Class stands out as a midsize luxury car that aims to be many things at once. It is described as the company’s most practical and versatile car, and it offers four body styles, four engines, and dozens of color schemes. That breadth gives it a wide appeal, whether a buyer wants something fast or efficient, loud or library quiet, modest or rich as hell. The 2021 model also brings a mid-cycle update for the infotainment system, engines, and exterior styling, which helps keep it feeling current.
Its strengths are easy to see in the test-drive notes: multiple powertrain options, great ride quality, and impressive technology. The summary also emphasizes that a brand-new Mercedes-Benz can make sense when money is only a mild concern, and owners praise the blend of luxury, performance, and beautiful design. At the same time, the E-Class is not without compromises. Advanced safety features are not standard, and some owners feel it is overpriced or note the absence of certain features such as active lane keeping assist.
Other model years to consider
- Average price: $39,339
- Good/great deal percentage: 35.5%
- User rating: 5 / 5
- Total listings: 1,080
- Average price: $30,639
- Good/great deal percentage: 36.8%
- User rating: 5 / 5
- Total listings: 1,005
- Average price: $23,083
- Good/great deal percentage: 36.9%
- User rating: 4.76 / 5
- Total listings: 1,293
This analysis is based on CarGurus' proprietary market data from September 28, 2026, CarGurus experts' opinions, and generative AI.
*CarGurus meticulously monitors the prices of millions of pre-owned vehicle listings, offering users precise and up-to-date market insights. Historical pricing data excludes any additional dealer fees as of May 3, 2026.
4.7 Overall rating
Filter by rating
ayekun j
Reviewed a 2021 Mercedes-Benz E 350 4MATIC on Mar 2, 2026
Johnson Ayekun, Best car money can buy,the E350 is in a class of excellent beautiful inside and out side,slik design, elegance meet with performance
Heather S
Reviewed a 2021 Mercedes-Benz E-Class on Jan 9, 2026
I love all the features, still learning a lot about them. I would seriously suggest reading the owners manual or watching some how to videos.
Elvis K. N
Reviewed a 2021 Mercedes-Benz E-Class on Jan 29, 2023
Very nice car but does not have active lane keeping assist.
Elvis E
Reviewed a 2021 Mercedes-Benz E 350 RWD on Apr 30, 2023
Best Car Ever! Great gas mileage. No problems so far at all! This is my 2nd Mercedes E-Class and I have no regrets buying it. Has great power. Can go really fast in seconds. If you like sporty exterior and luxury interior then this Mercedes Benz E350 2021 is the car for you!
Compare 2021 Mercedes-Benz E-Class Trims
The E-Class offers a range of trims from budget-friendly options to luxurious performance models, catering to various preferences and needs.
- Starting at $28,489
- Best MPG/MPGe: 23 city / 31 hwy
- Most Popular: E 350 4MATIC
Trim Overview
Prices updated weekly from CarGurus listings.
| E 350 RWD | E 350 4MATIC (Most Popular) | E 450 4MATIC Sedan AWD | E 450 Coupe RWD | E 450 4MATIC Coupe AWD | E 450 Cabriolet RWD | E 450 4MATIC Cabriolet AWD | AMG E 63 S Sedan 4MATIC | |
|---|---|---|---|---|---|---|---|---|
| Starting MSRP | $54,250 | $56,750 | $62,000 | $64,950 | $67,450 | $71,950 | $74,450 | $107,500 |
| Avg. Market Price | $28,489 | $29,718 | $36,117 | $34,059 | $43,714 | $45,604 | $40,745 | $78,038 |
| Positioning | Best value | AWD for less | AWD for less | Standard | Sport + AWD | Standard | Sport + AWD | Trail-ready |
| Standout Features | Navigation, heated seats | Bluetooth, navigation system | Backup camera, heated seats | Navigation, leather seats | Backup camera, leather seats | Heated seats, leather seats | Heated seats, leather seats | Adaptive suspension, navigation |
| Drivetrain | RWD | AWD | AWD | RWD | AWD | RWD | AWD | AWD |
| Listings Available | 517 | 940 | 90 | 70 | 57 | 62 | 39 | 76 |
Quick Compare Table
Listing prices sourced from CarGurus — updated weekly. OEM specs from manufacturer data.
| E 350 RWD | E 350 4MATIC | E 450 4MATIC Sedan AWD | E 450 Coupe RWD | E 450 4MATIC Coupe AWD | E 450 Cabriolet RWD | E 450 4MATIC Cabriolet AWD | AMG E 63 S Sedan 4MATIC | |
|---|---|---|---|---|---|---|---|---|
| AI Summary | Best value for a luxury sedan | Popular choice with AWD capability | More power with AWD performance | Stylish coupe with luxury features | Sporty coupe with AWD | Luxurious convertible with features | AWD convertible with luxury | High-performance luxury sedan |
| Avg. Market Price | $28,489 | $29,718 | $36,117 | $34,059 | $43,714 | $45,604 | $40,745 | $78,038 |
| MSRP | $54,250 | $56,750 | $62,000 | $64,950 | $67,450 | $71,950 | $74,450 | $107,500 |
| Engine | 2.0L 255 hp I4 | 2.0L 255 hp I4 | 3.0L 362 hp I6 | 3.0L 362 hp I6 | 3.0L 362 hp I6 | 3.0L 362 hp I6 | 3.0L 362 hp I6 | 4.0L 603 hp V8 |
| Drivetrain | RWD | AWD | AWD | RWD | AWD | RWD | AWD | AWD |
| MPG/MPGe (City/Hwy) | 22/31 | 22/30 | 23/30 | 23/31 | 23/30 | 23/30 | 23/29 | 16/23 |
| Navigation System | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ |
| Backup Camera | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ |
| Heated Seats | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ |
| Blind Spot Monitoring | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ |
| Bluetooth | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ |
| CarPlay | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ |
| Android Auto | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ |
| Parking Sensors | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ |
| Leather Seats | — | — | — | ✓ | ✓ | ✓ | ✓ | ✓ |
| Adaptive Suspension | — | — | — | — | — | — | — | ✓ |
| Active Listings | 517 | 940 | 90 | 70 | 57 | 62 | 39 | 76 |
Missing data displayed as "—".
Trim Deep Dives
E 350 RWD — "Who It's For"
The E 350 RWD is the pick for shoppers who want a luxury sedan experience without the higher price of AWD options.
- Avg. market price: $28,489 (updated weekly)
- MPG/MPGe: 22 city / 31 hwy
- Inventory: 517 listings
- View E 350 RWD listings
E 350 4MATIC — "Who It's For"
The E 350 4MATIC is the choice for those seeking all-wheel drive without a significant price increase, making it a popular option.
- Avg. market price: $29,718 (updated weekly)
- MPG/MPGe: 22 city / 30 hwy
- Inventory: 940 listings
- View E 350 4MATIC listings
E 450 4MATIC Sedan AWD — "Who It's For"
The E 450 4MATIC Sedan AWD is ideal for buyers wanting more power and luxury features, though availability is limited.
- Avg. market price: $36,117 (updated weekly)
- MPG/MPGe: 23 city / 30 hwy
- Inventory: 90 listings — lower availability; may limit negotiating room
- View E 450 4MATIC Sedan AWD listings
E 450 Coupe RWD — "Who It's For"
The E 450 Coupe RWD is perfect for those who desire a stylish coupe with luxury features without going for the AWD option.
- Avg. market price: $34,059 (updated weekly)
- MPG/MPGe: 23 city / 31 hwy
- Inventory: 70 listings — lower availability; may limit negotiating room
- View E 450 Coupe RWD listings
E 450 4MATIC Coupe AWD — "Who It's For"
The E 450 4MATIC Coupe AWD is for buyers wanting a sporty coupe with all-wheel drive, though availability is limited.
- Avg. market price: $43,714 (updated weekly)
- MPG/MPGe: 23 city / 30 hwy
- Inventory: 57 listings — lower availability; may limit negotiating room
- View E 450 4MATIC Coupe AWD listings
E 450 Cabriolet RWD — "Who It's For"
The E 450 Cabriolet RWD is ideal for those seeking a luxurious convertible experience without the AWD premium.
- Avg. market price: $45,604 (updated weekly)
- MPG/MPGe: 23 city / 30 hwy
- Inventory: 62 listings — lower availability; may limit negotiating room
- View E 450 Cabriolet RWD listings
E 450 4MATIC Cabriolet AWD — "Who It's For"
The E 450 4MATIC Cabriolet AWD is for buyers wanting a luxurious convertible with all-wheel drive, though availability is limited.
- Avg. market price: $40,745 (updated weekly)
- MPG/MPGe: 23 city / 29 hwy
- Inventory: 39 listings — lower availability; may limit negotiating room
- View E 450 4MATIC Cabriolet AWD listings
AMG E 63 S Sedan 4MATIC — "Who It's For"
The AMG E 63 S Sedan 4MATIC is the choice for performance enthusiasts seeking a high-powered luxury sedan.
- Avg. market price: $78,038 (updated weekly)
- MPG/MPGe: 16 city / 23 hwy
- Inventory: 76 listings — lower availability; may limit negotiating room
- View AMG E 63 S Sedan 4MATIC listings
Trim Recommendations
Most Popular — E 350 4MATIC
With 940 active listings, the E 350 4MATIC is the clear volume leader in the lineup.
Best Budget Option — E 350 RWD
At $28,489 avg market price — below the lineup median of $38,431 — it's the most accessible entry point.
Best for Fuel Economy — E 450 Coupe RWD
The E 450 Coupe RWD offers the best fuel economy in the lineup with 23 MPG city and 31 MPG highway.
Browse E 450 Coupe RWD listings
These recommendations are based on CarGurus' proprietary market data from September 24, 2026, CarGurus experts' opinions, and generative AI.
*CarGurus meticulously monitors the prices of millions of pre-owned vehicle listings, offering users precise and up-to-date market insights. Historical pricing data excludes any additional dealer fees as of May 3, 2026.
2021 Mercedes-Benz E-Class Price Trends
CarGurus tracks the prices of millions of used car listings every year. See how the average price of 2021 Mercedes-Benz E-Class prices has changed over time.
See more price trends2021 Mercedes-Benz E-Class Pricing Analysis
Pricing by Popular US Cities
Market Area: Nationwide
Key Insights
- Highest-Price Market: Philadelphia, PA leads with an average price of $57,188, indicating a premium market for the E-Class in this city.
- Best Value: Boston, MA offers the lowest average price at $30,465, suggesting a more competitive pricing environment for buyers.
- Inventory Drives Stability: New York, NY has the most listings at 219, which may contribute to more stable pricing dynamics in this market.
City-Level Pricing
| City | Total Listings | Avg Price |
|---|---|---|
| New York, NY | 219 | $33,687 |
| Atlanta, GA | 183 | $32,973 |
| Philadelphia, PA | 171 | $57,188 |
| Washington, DC | 171 | $35,377 |
| Chicago, IL | 167 | $44,028 |
| Dallas, TX | 157 | $43,934 |
| Miami, FL | 155 | $38,151 |
| Los Angeles, CA | 151 | $32,206 |
| Boston, MA | 148 | $30,465 |
| Houston, TX | 147 | $36,147 |
Pricing by Trim Packages
Key Insights
- Volume Leader: The E 350 4MATIC is the most listed trim with 985 units available, indicating strong demand for this configuration.
- Premium Spread: The AMG E 63 S Sedan 4MATIC has a high MSRP of $107,500, reflecting its luxury performance positioning within the lineup.
- Drivetrain Effect: All-wheel drive trims, such as the E 350 4MATIC, dominate listings, suggesting a preference for enhanced traction among buyers.
Trim-Level Details
| Trim | Listings | MSRP | Drivetrain | Engine |
|---|---|---|---|---|
| E 350 4MATIC | 985 | $56,750 | AWD | 2.0L 255 hp I4 |
| E 350 RWD | 523 | $54,250 | RWD | 2.0L 255 hp I4 |
| E 450 4MATIC Sedan AWD | 97 | $62,000 | AWD | 3.0L 362 hp I6 |
| AMG E 63 S Sedan 4MATIC | 76 | $107,500 | AWD | 4.0L 603 hp V8 |
| E 450 Coupe RWD | 70 | $64,950 | RWD | 3.0L 362 hp I6 |
| E 450 Cabriolet RWD | 70 | $71,950 | RWD | 3.0L 362 hp I6 |
| E 450 4MATIC Coupe AWD | 58 | $67,450 | AWD | 3.0L 362 hp I6 |
| E 450 4MATIC Cabriolet AWD | 43 | $74,450 | AWD | 3.0L 362 hp I6 |
Pricing Analysis by Model Year
Key Insights
- New-Car Premium: The 2027 model year shows an average price of $85,401, reflecting a 31.0% premium over its starting MSRP, indicating strong demand for newer models.
- Depreciation Curve: The 2016 model year exhibits the steepest depreciation at -68.8%, highlighting significant value loss over time.
- Best Value Sweet Spot: The 2023 model year is priced at $52,996, which is -6.6% below its MSRP, suggesting it may offer good value for buyers looking for a nearly new vehicle.
Model Year Pricing
| Model Year | Starting MSRP | Avg Price | Avg Price vs Starting MSRP |
|---|---|---|---|
| 2027 | $65,200 | $85,401 | +31.0% |
| 2026 | $63,900 | $72,546 | +13.5% |
| 2025 | $62,450 | $58,933 | -5.6% |
| 2024 | $62,300 | $53,740 | -13.7% |
| 2023 | $56,750 | $52,996 | -6.6% |
| 2022 | $54,950 | $39,720 | -27.7% |
| 2021 | $54,250 | $39,182 | -27.8% |
| 2020 | $54,050 | $32,776 | -39.4% |
| 2019 | $53,500 | $30,439 | -43.1% |
| 2018 | $52,950 | $26,592 | -49.8% |
| 2017 | $52,150 | $18,375 | -64.8% |
| 2016 | $52,650 | $16,438 | -68.8% |
These recommendations are based on CarGurus' proprietary market data from September 30, 2026, CarGurus experts' opinions, and generative AI.
*CarGurus meticulously monitors the prices of millions of pre-owned vehicle listings, offering users precise and up-to-date market insights. Historical pricing data excludes any additional dealer fees as of May 3, 2026.
How much does the 2021 Mercedes-Benz E-Class cost?
| Metric | Value |
|---|---|
| Current Average Price | $36,517 |
| Year-Round Low | $35,888 |
| Year-Round High | $41,815 |
| Average Price a Year Ago | $41,497 |
| Change vs. Last Year | −12.00% |
Prices have softened 12.00% compared to this time last year, making it a favorable time to shop this model year.
There are 828 listings available, which gives you a meaningful amount of inventory to compare.
Is the 2021 Mercedes-Benz E-Class a good car?
Yes — the 2021 Mercedes-Benz E-Class earns a 4.7/5 user rating and an 8.33/10 expert rating. The model scores 10/10 across Technology and Safety.
Owners consistently praise the blend of luxury, performance, and beautiful design, along with the comfortable interior and advanced features. The E-Class also stands out for its practical versatility and broad range of body styles and powertrains, so you can tailor it to the kind of driving you want.
The trade-offs are straightforward: some buyers feel it is overpriced, and advanced safety features are not standard. That makes it especially appealing if you value a richly appointed luxury car and are willing to pay for the right configuration.
With 35.4% of listings marked as good or great deals, the market still gives you some room to shop selectively.
Is the 2021 Mercedes-Benz E-Class reliable?
Owners rate it 4.7/5, a strong signal of long-term satisfaction.
The owner feedback points to a car that feels dependable in daily use, with praise for its comfortable interior, strong performance, and overall luxury experience. The expert notes also reinforce that impression by describing it as a quiet and excellent choice for a car this size, with a powertrain that feels smooth and composed in normal driving.
Mercedes also builds in some ownership-friendly touches, including a 48-volt system that helps the engine shut off more often and supports nearly vibration-free restarts in traffic. For used buyers, the main long-term risk is less about basic durability and more about the complexity and cost that can come with a heavily optioned luxury car.
What should I look for when buying a used 2021 Mercedes-Benz E-Class?
Accident-free inventory is solid at 75.1% — always verify the vehicle history report.
You should still run a vehicle history report on every candidate, even if the listing looks clean at first glance. Prioritize a pre-purchase inspection that checks electronics, suspension behavior, and any optional equipment that may be expensive to repair. Focus on condition and feature content, because this car can vary a lot depending on how it was optioned.
Key things to evaluate:
- Trim level: The cabin is richly finished even in baser trims, but the standing hood ornament is no longer part of the look, and the Sport style is more common than the classic Luxury package appearance.
- Powertrain: The lineup includes a revised 2.0-liter turbo four-cylinder, electrified inline-six powertrains, and a hand-built 4.0-liter V8 in the AMG E63 S; the base engine is described as underwhelming, while the six-cylinder and AMG setups are much stronger.
- Safety package: Forward automatic emergency braking, a driver-attention monitor, and blind-spot monitoring are standard, while all other driver-assist features are optional.
- Infotainment: The system uses MBUX with two 12-inch screens, touch and swipe controls, natural voice processing, and online search; Apple CarPlay and Android Auto are standard but not wireless, and the system does not update over-the-air.
- Fuel efficiency: The E53 sedan is rated at 25 mpg combined, the E63 sedan at 18 mpg combined, the E450 4Matic sedan at 26 mpg combined, and the E350 4Matic sedan at 25 mpg combined.
Which 2021 Mercedes-Benz E-Class trim should I buy?
The 2021 Mercedes-Benz E-Class is offered in 13 trim levels: E350, E450, AMG E53, and AMG E63 S.
Here's the short version:
- E350: This is the entry point if you want the E-Class experience at the lowest cost, but the base engine is the least convincing part of the lineup. It makes sense if you care more about the cabin, ride, and badge than outright performance.
- E450: This is the best-value choice for most shoppers because it brings the stronger electrified inline-six and keeps the car quiet, smooth, and genuinely quick without jumping all the way to AMG pricing.
- AMG E53: Choose this if you want sharper acceleration, rear-biased AWD, and the more athletic feel of the AMG setup without going to the extreme of the V8 model.
- AMG E63 S: This is the full-performance version, with a hand-built V8, lowered and widened chassis, and the most dramatic capability in the lineup.
The safety content also notes that some driver-assist features are optional, so check carefully for the equipment you want on any trim.
Is now a good time to buy a used 2021 Mercedes-Benz E-Class?
This looks like a moderate, selective buyer’s market, so you can shop carefully and still find worthwhile listings.
- Deal availability: 35.4% of listings are priced as good or great deals.
- Inventory: There are 828 listings available.
- Price trend: Prices have softened 12.00% compared with last year.
- Clean inventory: 75.1% of listings are accident-free.
If you find a listing below $35,888, that's toward the low end of the year-round range and worth acting on quickly.
What is the 2021 Mercedes-Benz E-Class's resale value?
The current average of $36,517 sits slightly below last year's $41,497.
That decline suggests the market has already adjusted downward, which can help you buy at a more favorable point in the cycle. If you plan to sell later, the current pricing trend means your future resale will depend heavily on mileage, condition, and equipment level.
Well-kept examples with desirable powertrains and strong option content should hold up better than stripped or heavily worn cars. The broader appeal of the E-Class also helps, since it offers enough variety to attract buyers looking for comfort, performance, or prestige.
Vehicles with strong owner satisfaction ratings, like this model year's 4.7/5, tend to retain buyer demand, which supports resale value over time.
Is the 2021 Mercedes-Benz E-Class safe?
The 2021 Mercedes-Benz E-Class sedan and wagon earn a five-star overall rating from NHTSA, with five-star ratings in frontal and side crash tests and for rollover vulnerability; the driver's side received a four-star rating in the frontal crash test.
It earns a 10/10 safety score from our experts.
Forward automatic emergency braking, a driver-attention monitor, and blind-spot monitoring are standard. Mercedes also includes features such as Pre-Safe Sound, side-bolster inflation in a side collision, and steering and brake interventions for crosswinds. However, many other driver-assist features remain optional, so you should confirm the exact safety equipment on any used example.
Should I buy a 2021 Mercedes-Benz E-Class or consider a different year?
If you're weighing the 2021 against nearby model years, here's how to think about it:
Choose the 2021 if:
- 35.4% of listings are priced as good or great deals.
- Accident-free inventory is solid at 75.1% — always verify the vehicle history report.
- Price trend: Prices have softened 12.00% compared with last year.
- Owners rate it 4.7/5 — a strong satisfaction signal.
- It brings a mid-cycle update to the infotainment system, engines, and exterior styling.
Consider the 2020 if:
- At $30,610, the 2020 costs less than the current year's $36,517 average.
- It offers the earlier E-Class formula with stellar design, technology, and effortless demeanor.
Consider the 2022 if:
- At $39,304, the 2022 costs more than the current year's $36,517 average.
- It carries forward the refreshed look and adds standard convenience features like automatic high beams.
The bottom line: If you want the best balance of updated tech, strong owner satisfaction, and a softer used-car price, the 2021 is the primary path to consider. If your budget is tighter, the 2020 can save you money, while the 2022 makes sense if you want the newer carryover setup and are willing to pay more.
These recommendations are based on CarGurus' proprietary market data from September 29, 2026, CarGurus experts' opinions, and generative AI.
*CarGurus meticulously monitors the prices of millions of pre-owned vehicle listings, offering users precise and up-to-date market insights. Historical pricing data excludes any additional dealer fees as of May 3, 2026.
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