Used 2021 Mercedes-Benz S-Class S 580 Sedan 4MATIC for SaleNationwide
163 vehicles found
Shop with transparent pricing.
Only show listings that include dealer fees- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Transmission:
- 9-Speed Automatic
- Mileage:
- 46,429
- Stock #:
- NN056588
- VIN:
- W1K6G7GB3MA056588
New arrival
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
46,429 mi
Union, NJ
Fair Deal
$58,589
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Anthracite Blue Metallic
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Porcelain/Espresso Brown
- Transmission:
- 9-Speed Automatic
- Mileage:
- 32,074
- Stock #:
- M23947
- VIN:
- W1K6G7GB3MA046577
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
32,074 mi
Huntsville, AL
Great Deal
$59,897
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Gray
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Red
- Transmission:
- 9-Speed Automatic
- Mileage:
- 35,102
- Stock #:
- DM231
- VIN:
- W1K6G7GB0MA052711
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
35,102 mi
Denver, CO
Good Deal
$59,990
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 80,861
- Stock #:
- C21009153
- VIN:
- W1K6G7GB9MA026057
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
80,861 mi
Wayne, MI
Great Deal
$44,515
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 56,895
- Stock #:
- AN04422
- VIN:
- W1K6G7GB6MA019082
Price drop
-$2,911
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
56,895 mi
Las Vegas, NV
Good Deal
$55,787
$52,876
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black Nappa
- Transmission:
- 9-Speed Automatic
- Mileage:
- 26,854
- Stock #:
- E231651
- VIN:
- W1K6G7GB0MA033950
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
26,854 mi
Santa Fe, NM
Great Deal
$62,387
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Gray
- Transmission:
- 9-Speed Automatic
- Mileage:
- 58,987
- Stock #:
- MA047653
- VIN:
- W1K6G7GB9MA047653
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
58,987 mi
Alpharetta, GA
Fair Deal
$55,597
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Graphite Gray
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Macchiato/Magma Gray
- Transmission:
- 9-Speed Automatic
- Mileage:
- 45,562
- Stock #:
- Z702239A
- VIN:
- W1K6G7GB0MA059545
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
45,562 mi
Duluth, GA
Good Deal
$55,045
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Graphite Gray
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Exclusive Silver Gray/Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 32,317
- Stock #:
- 025047F01
- VIN:
- W1K6G7GB1MA025047
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
32,317 mi
Ewing, NJ
Good Deal
$56,894
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Cirrus Silver
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 48,975
- Stock #:
- XH9163A
- VIN:
- W1K6G7GBXMA041750
Price drop
-$1,370
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
48,975 mi
Charlotte, NC
Good Deal
$59,455
$58,085
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Selenite Gray Metallic
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Sienna Brown/Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 68,332
- Stock #:
- MA049575
- VIN:
- W1K6G7GB3MA049575
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
68,332 mi
Lubbock, TX
Good Deal
$50,099
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 65,582
- Stock #:
- M23911A
- VIN:
- W1K6G7GB1MA018387
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
65,582 mi
Huntsville, AL
Fair Deal
$52,900
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Obsidian Black Metallic
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Exclusive Macchiato/Magma gray
- Transmission:
- 9-Speed Automatic
- Mileage:
- 36,525
- Stock #:
- P9090
- VIN:
- W1K6G7GB9MA048043
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
36,525 mi
Kansas City, MO
Fair Deal
$66,565
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- designo Diamond White Metallic
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Exclusive Sienna Brown/Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 35,927
- Stock #:
- U20754
- VIN:
- W1K6G7GB5MA057841
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
35,927 mi
Long Island City, NY
Fair Deal
$63,111
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Transmission:
- 9-Speed Automatic
- Mileage:
- 48,200
- Stock #:
- 023555
- VIN:
- W1K6G7GBXMA023555
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
48,200 mi
Tampa, FL
Good Deal
$57,480
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Mojave Silver Metallic
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Gray (Macchiato/Magma Grey)
- Transmission:
- Automatic
- Mileage:
- 31,195
- Stock #:
- TA195784A
- VIN:
- W1K6G7GB3MA035756
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
31,195 mi
Lafayette, LA
Great Deal
$58,790
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Silver
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black Premium L
- Transmission:
- 9-Speed Automatic
- Mileage:
- 12,648
- Stock #:
- ML1062
- VIN:
- W1K6G7GB2MA021055
New arrival
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
12,648 mi
Little Silver, NJ
Good Deal
$65,795
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Cirrus Silver Metallic
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 41,452
- Stock #:
- Y14751
- VIN:
- W1K6G7GB2MA054458
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
41,452 mi
Yorktown, VA
Great Deal
$56,174
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Silver
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 25,317
- Stock #:
- A2670338
- VIN:
- W1K6G7GB1MA026179
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
25,317 mi
Tucson, AZ
Good Deal
$61,541
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Manufaktur Diamon
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black Nappa
- Transmission:
- 9-Speed Automatic
- Mileage:
- 63,233
- Stock #:
- MA033909
- VIN:
- W1K6G7GB3MA033909
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
63,233 mi
Naples, FL
Good Deal
$51,196
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Obsidian Black Metallic
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 46,422
- Stock #:
- SZ181
- VIN:
- W1K6G7GB9MA035437
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
46,422 mi
Tiverton, RI
Good Deal
$59,275
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 76,354
- Stock #:
- T20537B
- VIN:
- W1K6G7GB9MA041321
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
76,354 mi
Shrewsbury, MA
Fair Deal
$49,894
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Selenite Gray
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 80,150
- Stock #:
- GX5618A
- VIN:
- W1K6G7GB3MA034042
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
80,150 mi
Joliet, IL
Fair Deal
$49,311
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Graphite Gray
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Macchiato/Magma Gray
- Transmission:
- 9-Speed Automatic
- Mileage:
- 57,505
- Stock #:
- B27983A
- VIN:
- W1K6G7GB0MA019434
New arrival
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
57,505 mi
Grand Rapids, MI
Fair Deal
$55,314
Overview
The Mercedes-Benz S-Class S 580 4MATIC Sedan AWD is part of a generation that was introduced for the 2021 model year. This big luxury sedan boasts twin-turbocharged V8 power with a mild-hybrid system, and slots under the ultra-luxury Maybach versions of the S-Class. It’s a great car for those with chauffeurs, since the upscale and comfortable cabin can be upgraded with amenities such as pop-out tables and massaging rear seats with pillows and leg rests. Consider the Audi A7 and Genesis G80 as well if you’re shopping for the Mercedes-Benz S-Class S 580 4MATIC Sedan AWD.
Key Features
- 4.0-liter twin-turbocharged V8 engine
- All-wheel drive
- Sedan body style
- Available Executive Rear Seat package
Pricing Details
The 2023 Mercedes-Benz S-Class S 580 4MATIC Sedan AWD has an MSRP of $124,000. The S-Class was fully redesigned for 2021, which is when this trim was introduced, and had an MSRP of $116,300. Used examples on CarGurus range from $43,994.00 to $89,000.00 with an average price of $57,824.79.
Specifications
Performance
Engine
4.0-liter twin-turbocharged V8 engine
Transmission
Nine-speed automatic transmission
Drivetrain
All-wheel drive
Horsepower/Torque
496 hp/516 lb-ft
0-60 mph
4.0 seconds (estimated)
MPG
18 mpg city, 27 highway, 21 combined
Curb weight
4,762 pounds
Dimensions
wheelbase
126.6 inches
length
208.2 inches
width
76.9 inches
height
59.2 inches
*CarGurus meticulously monitors the prices of millions of pre-owned vehicle listings, offering users precise and up-to-date market insights. Historical pricing data excludes any additional dealer fees as of May 3, 2026.
FAQs
How much does the Mercedes-Benz S-Class S 580 Sedan 4MATIC cost?
The average Mercedes-Benz S-Class S 580 Sedan 4MATIC costs about $58,326.87. The average price has decreased by -6% since last year. The 163 for sale on CarGurus range from $43,994 to $89,000 in price.
How many Mercedes-Benz S-Class S 580 Sedan 4MATIC vehicles have no reported accidents or damage?
127 out of 163 for sale have no reported accidents or damage.
What is the fuel economy of the Mercedes-Benz S-Class S 580 Sedan 4MATIC?
Depending on the engine and options, the Mercedes-Benz S-Class S 580 Sedan 4MATIC gets between 20 and 20 MPG/MPGe.
What fuel types are available?
Gasoline engines are available.
*CarGurus meticulously monitors the prices of millions of pre-owned vehicle listings, offering users precise and up-to-date market insights. Historical pricing data excludes any additional dealer fees as of May 3, 2026.
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