Used 2022 Lexus RX 350 F SPORT Handling AWD for SaleNationwide
74 vehicles found
Shop with transparent pricing.
Only show listings that include dealer fees- Year:
- 2022
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Nebula Gray Pearl
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 8-Speed Automatic
- Mileage:
- 59,071
- Stock #:
- C342532
- VIN:
- 2T2YZMDA4NC342532
2022 Lexus RX
350 F SPORT Handling AWD
59,071 mi
Orlando, FL
Great Deal
$36,499
- Year:
- 2022
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Black (Caviar)
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Circuit Red
- Transmission:
- 8-Speed Automatic
- Mileage:
- 97,152
- Stock #:
- I324092
- VIN:
- 2T2YZMDA0NC324092
2022 Lexus RX
350 F SPORT Handling AWD
97,152 mi
Clermont, FL
Fair Deal
$32,500
- Year:
- 2022
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Ultra White
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Circuit Red
- Transmission:
- 8-Speed Automatic
- Mileage:
- 44,177
- Stock #:
- NC362224A
- VIN:
- 2T2YZMDA5NC362224
2022 Lexus RX
350 F SPORT Handling AWD
44,177 mi
San Antonio, TX
Fair Deal
$42,991
- Year:
- 2022
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Gray
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 55,366
- Stock #:
- CPO7729A
- VIN:
- 2T2YZMDA5NC312407
2022 Lexus RX
350 F SPORT Handling AWD
55,366 mi
Tampa, FL
Great Deal
$37,245
- Year:
- 2022
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Ultra White
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Circuit Red
- Transmission:
- 8-Speed Automatic
- Mileage:
- 44,284
- Stock #:
- NC367006
- VIN:
- 2T2YZMDA9NC367006
2022 Lexus RX
350 F SPORT Handling AWD
44,284 mi
Englewood, CO
Good Deal
$43,697
- Year:
- 2022
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Ultra White
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Circuit Red
- Transmission:
- Automatic
- Mileage:
- 41,209
- Stock #:
- T01259A
- VIN:
- 2T2YZMDA6NC355606
2022 Lexus RX
350 F SPORT Handling AWD
41,209 mi
Charleston, SC
Good Deal
$44,448
- Year:
- 2022
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Mica
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Circuit Red
- Transmission:
- 8-Speed Automatic
- Mileage:
- 31,855
- Stock #:
- SB4270
- VIN:
- 2T2YZMDA6NC320886
2022 Lexus RX
350 F SPORT Handling AWD
31,855 mi
Quakertown, PA
Fair Deal
$43,753
- Year:
- 2022
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Ultra White
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Circuit Red w/Scored Aluminum Trim
- Transmission:
- 8-Speed Automatic
- Mileage:
- 132,742
- Stock #:
- 314835
- VIN:
- 2T2YZMDA3NC314835
2022 Lexus RX
350 F SPORT Handling AWD
132,742 mi
Houston, TX
Fair Deal
$30,136
- Year:
- 2022
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Silver
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Circuit Red
- Transmission:
- 8-Speed Automatic
- Mileage:
- 53,791
- Stock #:
- P591909A
- VIN:
- 2T2YZMDA7NC347398
2022 Lexus RX
350 F SPORT Handling AWD
53,791 mi
Jacksonville, FL
Good Deal
$39,916
- Year:
- 2022
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Cloudburst Gray
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Circuit Red
- Transmission:
- 8-Speed Automatic
- Mileage:
- 53,776
- Stock #:
- T64009B
- VIN:
- 2T2YZMDA9NC311132
New arrival
2022 Lexus RX
350 F SPORT Handling AWD
53,776 mi
Prescott, AZ
Good Deal
$39,369
- Year:
- 2022
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Gray Pearl
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Circuit Red
- Transmission:
- 8-Speed Automatic
- Mileage:
- 72,518
- Stock #:
- T0572A
- VIN:
- 2T2YZMDA8NC324860
2022 Lexus RX
350 F SPORT Handling AWD
72,518 mi
Clearwater, FL
Fair Deal
$38,289
- Year:
- 2022
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Gray Pearl
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Circuit Red
- Transmission:
- 8-Speed Automatic
- Mileage:
- 49,761
- Stock #:
- NT283377A
- VIN:
- 2T2YZMDA4NC337802
2022 Lexus RX
350 F SPORT Handling AWD
49,761 mi
Harvey, LA
Fair Deal
$41,936
- Year:
- 2022
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Mica
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 8-Speed Automatic
- Mileage:
- 69,743
- Stock #:
- T1103A
- VIN:
- 2T2YZMDA3NC320859
2022 Lexus RX
350 F SPORT Handling AWD
69,743 mi
San Antonio, TX
Good Deal
$37,078
- Year:
- 2022
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Ultra White
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Circuit Red
- Transmission:
- 8-Speed Automatic
- Mileage:
- 32,205
- Stock #:
- 26J0692A
- VIN:
- 2T2YZMDA7NC326857
Price drop
-$1,112
2022 Lexus RX
350 F SPORT Handling AWD
32,205 mi
Delray Beach, FL
Great Deal
$40,843
$39,731
- Year:
- 2022
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 107,042
- Stock #:
- U314749
- VIN:
- 2T2YZMDAXNC314749
2022 Lexus RX
350 F SPORT Handling AWD
107,042 mi
Oakland Park, FL
Fair Deal
$30,525
- Year:
- 2022
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- White
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Transmission:
- Automatic
- Mileage:
- 88,121
- Stock #:
- 2046524A
- VIN:
- 2T2YZMDA5NC358139
New arrival
2022 Lexus RX
350 F SPORT Handling AWD
88,121 mi
Sarasota, FL
Good Deal
$32,991
- Year:
- 2022
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Atomic Silver
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Circuit Red
- Transmission:
- 8-Speed Automatic
- Mileage:
- 52,204
- Stock #:
- NC342162
- VIN:
- 2T2YZMDA8NC342162
2022 Lexus RX
350 F SPORT Handling AWD
52,204 mi
Arlington, TX
Good Deal
$39,519
- Year:
- 2022
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Matador Red Mica
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 8-Speed Automatic
- Mileage:
- 39,669
- Stock #:
- TC312803
- VIN:
- 2T2YZMDA2NC312803
2022 Lexus RX
350 F SPORT Handling AWD
39,669 mi
Huntsville, AL
Good Deal
$43,994
- Year:
- 2022
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Silver
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Circuit Red
- Transmission:
- 8-Speed Automatic
- Mileage:
- 43,879
- Stock #:
- T62065
- VIN:
- 2T2YZMDAXNC350053
2022 Lexus RX
350 F SPORT Handling AWD
43,879 mi
La Quinta, CA
Fair Deal
$43,067
- Year:
- 2022
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Black (Caviar)
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 74,446
- Stock #:
- 351509
- VIN:
- 2T2YZMDAXNC351509
2022 Lexus RX
350 F SPORT Handling AWD
74,446 mi
Plano, TX
Fair Deal
$37,223
- Year:
- 2022
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Ultra White
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Circuit Red
- Transmission:
- 8-Speed Automatic
- Mileage:
- 47,111
- Stock #:
- L26NX196A
- VIN:
- 2T2YZMDA6NC354312
New arrival
2022 Lexus RX
350 F SPORT Handling AWD
47,111 mi
Clive, IA
Fair Deal
$45,379
- Year:
- 2022
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Atomic Silver
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Circuit Red
- Transmission:
- 8-Speed Automatic
- Mileage:
- 50,312
- Stock #:
- GT201723A
- VIN:
- 2T2YZMDA5NC358125
New arrival
2022 Lexus RX
350 F SPORT Handling AWD
50,312 mi
Englewood, CO
Good Deal
$40,599
- Year:
- 2022
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Nebula Gray Pearl
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 8-Speed Automatic
- Mileage:
- 73,665
- Stock #:
- NC348872
- VIN:
- 2T2YZMDA3NC348872
2022 Lexus RX
350 F SPORT Handling AWD
73,665 mi
Parker, CO
Good Deal
$36,113
- Year:
- 2022
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Nebula Gray Pearl
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Circuit Red
- Transmission:
- 8-Speed Automatic
- Mileage:
- 27,403
- Stock #:
- NC350172
- VIN:
- 2T2YZMDA7NC350172
New arrival
2022 Lexus RX
350 F SPORT Handling AWD
27,403 mi
Richardson, TX
Fair Deal
$43,712
FAQs
How much does the Lexus RX 350 F SPORT Handling AWD cost?
The average Lexus RX 350 F SPORT Handling AWD costs about $37,855.00. The average price has decreased by -7.1% since last year. The 437 for sale on CarGurus range from $29,573 to $64,817 in price.
How many Lexus RX 350 F SPORT Handling AWD vehicles have no reported accidents or damage?
360 out of 437 for sale have no reported accidents or damage.
What is the fuel economy of the Lexus RX 350 F SPORT Handling AWD?
Depending on the engine and options, the Lexus RX 350 F SPORT Handling AWD gets between 22 and 24 MPG/MPGe.
What fuel types are available?
Gasoline engines are available.
*CarGurus meticulously monitors the prices of millions of pre-owned vehicle listings, offering users precise and up-to-date market insights. Historical pricing data excludes any additional dealer fees as of May 3, 2026.
Relevant articles
CarGurus Editorial Team
Best Lexus Deals in November 2026
Leasing a Lexus can be a great way to get into a new car from one of the most popular luxury brands at a more affordable monthly rate. Here are the best deals we've found this month on Lexus vehicles.
CarGurus Editorial Team
The Best Midsize SUVs in 2026
The midsize SUV segment is growing fast and fiercely competitive. Terrible models are few and far between; what you will find are 50 shades of better or best.
Christian Wardlaw
The Best Used Midsize SUVs in 2026
Family-friendly SUVs are more expensive than ever, but you can still find good deals if you know where to look. Here, we’ve got used midsize SUV recommendations at four price points under $40,000.
All Used CarsManual Transmission CarsLuxury CarsCars with Red InteriorCheap Manual CarsHybrid CarsSports CarsElectric SUVsCheap TrucksSmall CarsThird Row SUVsThree Quarter Ton TrucksLifted TrucksManual Transmission TrucksDiesel TrucksHybrid SUVsDually TrucksOne Ton TrucksCheap SUVsLifted Ford Trucks4x4 TrucksWork TrucksAWD SUVsFord TrucksChevrolet TrucksToyota TrucksTrucks Under $10,000Cars Under $15,000Sports Cars Under $20,000Trucks Under $20,000Used Sedans for Sale with Low MileageUsed SUVs / Crossovers for Sale with Low MileageUsed Hatchbacks for Sale with Low MileageUsed Convertibles for Sale with Low MileageUsed Vans for Sale with Low MileageUsed Minivans for Sale with Low MileageUsed Pickup Trucks for Sale with Low MileageUsed Coupes for Sale with Low MileageUsed Wagons for Sale with Low Mileage
