Used 2022 Mercedes-Benz CLS 450 4MATIC for SaleNationwide
31 vehicles found
Shop with transparent pricing.
Only show listings that include dealer fees- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- MANUFAKTUR Diamond White Bright
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (Macchiato Beige/Magma Gray)
- Transmission:
- 9-Speed Automatic
- Mileage:
- 21,251
- Stock #:
- TD030931A
- VIN:
- W1K2J5KB3NA101445
2022 Mercedes-Benz CLS
450 4MATIC
21,251 mi
West Palm Beach, FL
Good Deal
$45,516
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Selenite Gray Metallic
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Sienna Brown/Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 9,327
- Stock #:
- U4956
- VIN:
- W1K2J5KB4NA104628
2022 Mercedes-Benz CLS
450 4MATIC
9,327 mi
Mamaroneck, NY
Great Deal
$44,465
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Black
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 39,042
- Stock #:
- BW6641
- VIN:
- W1K2J5KB1NA104960
2022 Mercedes-Benz CLS
450 4MATIC
39,042 mi
Solon, OH
Fair Deal
$41,520
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Selenite Gray Metallic
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 24,853
- Stock #:
- L264912B
- VIN:
- W1K2J5KB9NA107847
New arrival
2022 Mercedes-Benz CLS
450 4MATIC
24,853 mi
Collinsville, IL
Good Deal
$47,872
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Polar White
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 56,639
- Stock #:
- 098632C01
- VIN:
- W1K2J5KB7NA098632
Price drop
-$1,000
2022 Mercedes-Benz CLS
450 4MATIC
56,639 mi
Streetsboro, OH
Great Deal
$35,447
$34,447
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Gray
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 40,102
- Stock #:
- TNA106175
- VIN:
- W1K2J5KB3NA106175
Price drop
-$2,080
2022 Mercedes-Benz CLS
450 4MATIC
40,102 mi
Los Angeles, CA
Fair Deal
$43,076
$41,076
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Gray (MANUFAKTUR Signature Graphite Metallic)
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Classic Red/Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 41,862
- Stock #:
- 104709
- VIN:
- W1K2J5KB4NA104709
2022 Mercedes-Benz CLS
450 4MATIC
41,862 mi
Plano, TX
Fair Deal
$42,125
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Polar White
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 28,623
- Stock #:
- 14437
- VIN:
- W1K2J5KB3NA100019
2022 Mercedes-Benz CLS
450 4MATIC
28,623 mi
Tigard, OR
Great Deal
$41,732
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Gray Metallic
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 47,009
- Stock #:
- G300426A
- VIN:
- W1K2J5KB7NA096217
2022 Mercedes-Benz CLS
450 4MATIC
47,009 mi
Springfield, VA
Fair Deal
$42,748
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Silver
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 43,896
- Stock #:
- AB7883
- VIN:
- W1K2J5KB4NA101213
2022 Mercedes-Benz CLS
450 4MATIC
43,896 mi
Westborough, MA
Fair Deal
$43,075
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- MANUFAKTUR Mystic Blue
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Deep White/Black
- Transmission:
- Automatic
- Mileage:
- 35,309
- Stock #:
- NA101914
- VIN:
- W1K2J5KB1NA101914
2022 Mercedes-Benz CLS
450 4MATIC
35,309 mi
West Chester, PA
Good Deal
$43,970
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Gray
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown
- Transmission:
- 9-Speed Automatic
- Mileage:
- 42,413
- Stock #:
- FT08939
- VIN:
- W1K2J5KB1NA095354
2022 Mercedes-Benz CLS
450 4MATIC
42,413 mi
Paterson, NJ
Fair Deal
$42,784
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Graphite Gray Metallic
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Sienna Brown/Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 45,448
- Stock #:
- NA105198
- VIN:
- W1K2J5KBXNA105198
2022 Mercedes-Benz CLS
450 4MATIC
45,448 mi
City Of Industry, CA
Good Deal
$39,392
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Gold
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown
- Transmission:
- Automatic
- Mileage:
- 28,655
- Stock #:
- 70165888
- VIN:
- W1K2J5KBXNA099094
Price drop
-$1,000
2022 Mercedes-Benz CLS
450 4MATIC
28,655 mi
Canoga Park, CA
Good Deal
$43,998
$42,998
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Cirrus Silver Metallic
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (Macchiato Beige/Magma Gray)
- Transmission:
- 9-Speed Automatic
- Mileage:
- 13,665
- Stock #:
- P6120
- VIN:
- W1K2J5KB9NA098521
Price drop
-$1,200
2022 Mercedes-Benz CLS
450 4MATIC
13,665 mi
Willoughby, OH
Fair Deal
$51,882
$50,682
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Black
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 58,531
- Stock #:
- J0645T
- VIN:
- W1K2J5KB6NA100645
2022 Mercedes-Benz CLS
450 4MATIC
58,531 mi
Fishers, IN
Good Deal
$37,599
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- MANUFAKTUR Diamond White Bright
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Sienna Brown/Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 30,317
- Stock #:
- ZNA105046
- VIN:
- W1K2J5KB9NA105046
2022 Mercedes-Benz CLS
450 4MATIC
30,317 mi
Cincinnati, OH
Fair Deal
$47,164
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Black
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 14,036
- Stock #:
- NA104671
- VIN:
- W1K2J5KB5NA104671
New arrival
2022 Mercedes-Benz CLS
450 4MATIC
14,036 mi
Hanover, MA
Good Deal
$50,455
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Polar White
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 24,657
- Stock #:
- A098498B
- VIN:
- W1K2J5KB7NA098498
Price drop
-$1,799
2022 Mercedes-Benz CLS
450 4MATIC
24,657 mi
Greenwich, CT
Fair Deal
$49,649
$48,649
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Black
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (TAN)
- Transmission:
- Automatic
- Mileage:
- 38,734
- Stock #:
- 28996990
- VIN:
- W1K2J5KB7NA105112
New arrival
2022 Mercedes-Benz CLS
450 4MATIC
38,734 mi
Huntsville, AL
Fair Deal
$45,998
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Gray
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 26,745
- Stock #:
- 70197239
- VIN:
- W1K2J5KB6NA090330
New arrival
2022 Mercedes-Benz CLS
450 4MATIC
26,745 mi
Madison, TN
Fair Deal
$46,998
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Graphite Gray Metallic
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 25,647
- Stock #:
- 097540
- VIN:
- W1K2J5KB8NA097540
2022 Mercedes-Benz CLS
450 4MATIC
25,647 mi
McKinney, TX
Fair Deal
$47,365
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Black
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 48,454
- Stock #:
- 839
- VIN:
- W1K2J5KB7NA107586
2022 Mercedes-Benz CLS
450 4MATIC
48,454 mi
Modesto, CA
Fair Deal
$40,127
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Black
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Magma Gray/Macchiato Beige
- Transmission:
- 9-Speed Automatic
- Mileage:
- 22,268
- Stock #:
- 099928CM1
- VIN:
- W1K2J5KB0NA099928
Price drop
-$1,000
2022 Mercedes-Benz CLS
450 4MATIC
22,268 mi
Parma, OH
No Rating
$43,499
$42,499
3.0 Overall rating
Filter by rating
John S
Reviewed a 2022 Mercedes-Benz 450 4MATIC on Oct 15, 2025
It’s a little overpriced for a vehicle that is no longer in production
Is this review helpful?
FAQs
How much does the Mercedes-Benz CLS 450 4MATIC cost?
The average Mercedes-Benz CLS 450 4MATIC costs about $43,800.10. The average price has decreased by -3.8% since last year. The 160 for sale on CarGurus range from $20,433 to $66,167 in price.
How many Mercedes-Benz CLS 450 4MATIC vehicles have no reported accidents or damage?
125 out of 160 for sale have no reported accidents or damage.
What is the fuel economy of the Mercedes-Benz CLS 450 4MATIC?
Depending on the engine and options, the Mercedes-Benz CLS 450 4MATIC gets between 25 and 26 MPG (or EV battery range).
What fuel types are available?
Gasoline engines are available.
*CarGurus meticulously monitors the prices of millions of pre-owned vehicle listings, offering users precise and up-to-date market insights. Historical pricing data excludes any additional dealer fees as of May 3, 2026.
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