Used 2022 Mercedes-Benz CLS 450 4MATIC for SaleNationwide
30 vehicles found
Shop with transparent pricing.
Only show listings that include dealer fees- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Gray (Graphite Grey Metallic)
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Sienna Brown/Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 45,936
- Stock #:
- TT216A
- VIN:
- W1K2J5KB8NA095416
New arrival
2022 Mercedes-Benz CLS
450 4MATIC
45,936 mi
Knoxville, TN
Fair Deal
$44,790
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Gray (MANUFAKTUR Signature Graphite Metallic)
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Classic Red/Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 41,863
- Stock #:
- 104709
- VIN:
- W1K2J5KB4NA104709
2022 Mercedes-Benz CLS
450 4MATIC
41,863 mi
Plano, TX
Fair Deal
$39,413
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Cirrus Silver Metallic
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (Macchiato Beige/Magma Gray)
- Transmission:
- 9-Speed Automatic
- Mileage:
- 13,665
- Stock #:
- P6120
- VIN:
- W1K2J5KB9NA098521
2022 Mercedes-Benz CLS
450 4MATIC
13,665 mi
Willoughby, OH
Good Deal
$45,438
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Blue
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Gray
- Transmission:
- Automatic
- Mileage:
- 59,714
- Stock #:
- CBMPNA104025
- VIN:
- W1K2J5KB7NA104025
2022 Mercedes-Benz CLS
450 4MATIC
59,714 mi
Midlothian, VA
Fair Deal
$37,349
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Gray
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 40,102
- Stock #:
- SNA106175
- VIN:
- W1K2J5KB3NA106175
Price drop
-$3,070
2022 Mercedes-Benz CLS
450 4MATIC
40,102 mi
Calabasas, CA
Great Deal
$39,166
$36,266
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Selenite Gray Metallic
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (Macchiato Beige/Magma Gray)
- Transmission:
- 9-Speed Automatic
- Mileage:
- 31,401
- Stock #:
- NA100409A
- VIN:
- W1K2J5KB5NA100409
2022 Mercedes-Benz CLS
450 4MATIC
31,401 mi
Hawthorne, CA
Good Deal
$39,120
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Polar White
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 28,623
- Stock #:
- 14437
- VIN:
- W1K2J5KB3NA100019
2022 Mercedes-Benz CLS
450 4MATIC
28,623 mi
Tigard, OR
Good Deal
$41,552
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Polar White
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Classic Red/Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 50,297
- Stock #:
- SU35942T
- VIN:
- W1K2J5KB4NA098944
2022 Mercedes-Benz CLS
450 4MATIC
50,297 mi
Farmingdale, NY
Fair Deal
$38,170
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Obsidian Black Metallic
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Sienna Brown/Black
- Transmission:
- Automatic
- Mileage:
- 71,678
- Stock #:
- CT88709C
- VIN:
- W1K2J5KB2NA095637
Price drop
-$2,023
2022 Mercedes-Benz CLS
450 4MATIC
71,678 mi
Charlotte, NC
Fair Deal
$38,734
$36,711
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Gray
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 21,502
- Stock #:
- 095986
- VIN:
- W1K2J5KB5NA095986
2022 Mercedes-Benz CLS
450 4MATIC
21,502 mi
Roswell, GA
Fair Deal
$47,697
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- MANUFAKTUR Diamond White Bright
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Classic Red/Black
- Transmission:
- Automatic
- Mileage:
- 42,672
- Stock #:
- 108134
- VIN:
- W1K2J5KBXNA108134
2022 Mercedes-Benz CLS
450 4MATIC
42,672 mi
Murrieta, CA
Fair Deal
$39,900
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- MANUFAKTUR Diamond White Bright
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Yacht Blue/Black
- Transmission:
- Automatic
- Mileage:
- 13,459
- Stock #:
- NA099144B
- VIN:
- W1K2J5KBXNA099144
2022 Mercedes-Benz CLS
450 4MATIC
13,459 mi
Montclair, CA
Great Deal
$41,884
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Gray
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 62,636
- Stock #:
- AB8032
- VIN:
- W1K2J5KB8NA096095
2022 Mercedes-Benz CLS
450 4MATIC
62,636 mi
Westborough, MA
Fair Deal
$38,385
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Graphite Gray Metallic
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 25,647
- Stock #:
- 097540
- VIN:
- W1K2J5KB8NA097540
2022 Mercedes-Benz CLS
450 4MATIC
25,647 mi
McKinney, TX
Good Deal
$42,195
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Black
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black Leather
- Transmission:
- 9-Speed Automatic
- Mileage:
- 34,382
- Stock #:
- BK2804T
- VIN:
- W1K2J5KB2NA101131
New arrival
2022 Mercedes-Benz CLS
450 4MATIC
34,382 mi
Brooklyn, NY
Fair Deal
$43,165
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Diamond White
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (Macchiato Beige/ Magma Grey Leat)
- Transmission:
- 9-Speed Automatic
- Mileage:
- 43,457
- Stock #:
- SL3579A
- VIN:
- W1K2J5KB1NA108264
2022 Mercedes-Benz CLS
450 4MATIC
43,457 mi
Canonsburg, PA
Fair Deal
$42,990
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Obsidian Black Metallic
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 32,953
- Stock #:
- NA100714
- VIN:
- W1K2J5KBXNA100714
2022 Mercedes-Benz CLS
450 4MATIC
32,953 mi
Minneapolis, MN
Fair Deal
$43,349
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Gray
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 26,753
- Stock #:
- 70197239
- VIN:
- W1K2J5KB6NA090330
Price drop
-$1,000
2022 Mercedes-Benz CLS
450 4MATIC
26,753 mi
Tallahassee, FL
Great Deal
$41,998
$40,998
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Gray
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown
- Transmission:
- Automatic
- Mileage:
- 47,017
- Stock #:
- M11304B
- VIN:
- W1K2J5KB0NA096284
2022 Mercedes-Benz CLS
450 4MATIC
47,017 mi
Cherry Hill, NJ
Fair Deal
$43,698
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Cirrus Silver Metallic
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Neva Gray/Magma Gray
- Transmission:
- 9-Speed Automatic
- Mileage:
- 9,657
- Stock #:
- 77067A
- VIN:
- W1K2J5KB7NA104624
2022 Mercedes-Benz CLS
450 4MATIC
9,657 mi
Reading, PA
Good Deal
$49,500
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Gray (Selenite Grey Metallic)
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 29,690
- Stock #:
- D9928A
- VIN:
- W1K2J5KB8NA100906
2022 Mercedes-Benz CLS
450 4MATIC
29,690 mi
Pleasant Grove, UT
Good Deal
$39,994
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- White
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown
- Transmission:
- 9-Speed Automatic
- Mileage:
- 64,618
- Stock #:
- L23001
- VIN:
- W1K2J5KB5NA108168
2022 Mercedes-Benz CLS
450 4MATIC
64,618 mi
Lehi, UT
Fair Deal
$35,793
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Polar White
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Sienna Brown/Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 3,929
- Stock #:
- U50889
- VIN:
- W1K2J5KB9NA108156
2022 Mercedes-Benz CLS
450 4MATIC
3,929 mi
Roslyn, NY
Good Deal
$50,174
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Gray
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 55,495
- Stock #:
- J1709
- VIN:
- W1K2J5KB7NA107782
2022 Mercedes-Benz CLS
450 4MATIC
55,495 mi
San Diego, CA
Fair Deal
$38,985
3.0 Overall rating
Filter by rating
John S
Reviewed a 2022 Mercedes-Benz 450 4MATIC on Oct 15, 2025
It’s a little overpriced for a vehicle that is no longer in production
Is this review helpful?
FAQs
How much does the Mercedes-Benz CLS 450 4MATIC cost?
The average Mercedes-Benz CLS 450 4MATIC costs about $43,800.10. The average price has decreased by -3.2% since last year. The 193 for sale on CarGurus range from $17,871 to $65,284 in price.
How many Mercedes-Benz CLS 450 4MATIC vehicles have no reported accidents or damage?
141 out of 193 for sale have no reported accidents or damage.
What is the fuel economy of the Mercedes-Benz CLS 450 4MATIC?
Depending on the engine and options, the Mercedes-Benz CLS 450 4MATIC gets between 25 and 26 MPG/MPGe.
What fuel types are available?
Gasoline engines are available.
*CarGurus meticulously monitors the prices of millions of pre-owned vehicle listings, offering users precise and up-to-date market insights. Historical pricing data excludes any additional dealer fees as of May 3, 2026.
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