Used 2022 Mercedes-Benz CLS for SaleNationwide
126 vehicles found
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Polar White
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 96,207
- Stock #:
- P2579
- VIN:
- W1K2J5JB9MA093318

2021 Mercedes-Benz CLS
450 RWD
96,207 mi
$28,973
- Year:
- 2023
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- MANUFAKTUR Signature Arabian Gray
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 51,765
- Stock #:
- PA112679
- VIN:
- W1K2J5KB2PA112679

2023 Mercedes-Benz CLS
450 4MATIC
51,765 mi
$44,900
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Obsidian Black Metallic
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 64,654
- Stock #:
- 091872
- VIN:
- W1K2J5JB3MA091872

2021 Mercedes-Benz CLS
450 RWD
64,654 mi
$35,724
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- 3M Wrap Film 2080 Satin Dark Gray
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 48,940
- Stock #:
- P6632
- VIN:
- W1K2J5KB6MA086633

2021 Mercedes-Benz CLS
450 4MATIC
48,940 mi
$36,499
- Year:
- 2023
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Black
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 12,286
- Stock #:
- EC0517
- VIN:
- W1K2J5KBXPA111358

2023 Mercedes-Benz CLS
450 4MATIC
12,286 mi
$55,495
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Obsidian Black Metallic
- Combined gas mileage:
- 23 MPG
- Fuel type:
- Gasoline
- Interior color:
- designo Black/Titanium Gray Pearl
- Transmission:
- 9-Speed Automatic
- Mileage:
- 52,251
- Stock #:
- 086191
- VIN:
- W1K2J6BB3MA086191

2021 Mercedes-Benz CLS
AMG CLS 53 4MATIC
52,251 mi
$46,473
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Gray ([992] Selenite Grey Metallic)
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 1,174
- VIN:
- W1K2J5KB1MA091836
![Gray ([992] Selenite Grey Metallic) 2021 Mercedes-Benz CLS Coupe All-Wheel Drive Automatic](https://static.cargurus.com/images/forsale/2026/01/13/00/58/2021_mercedes-benz_cls-pic-832979311599051558-1024x768.jpeg?io=true&width=640&height=480&fit=bounds&format=jpg&auto=webp)
-$1,000
2021 Mercedes-Benz CLS
450 4MATIC
1,174 mi
$39,950
$38,950
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Cirrus Silver Metallic
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 23,116
- Stock #:
- PJ12745
- VIN:
- W1K2J5KB7NA099411

2022 Mercedes-Benz CLS
450 4MATIC
23,116 mi
$45,153
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Obsidian Black Metallic
- Combined gas mileage:
- 23 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 43,987
- Stock #:
- VM090436
- VIN:
- W1K2J6BB5MA090436

-$1,301
2021 Mercedes-Benz CLS
AMG CLS 53 4MATIC
43,987 mi
$47,740
$46,439
- Year:
- 2023
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Black
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 22,395
- Stock #:
- 26-152
- VIN:
- W1K2J5KB8PA118521

2023 Mercedes-Benz CLS
450 4MATIC
22,395 mi
$55,893
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Gray
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown
- Transmission:
- 9-Speed Automatic
- Mileage:
- 60,440
- Stock #:
- NA096096
- VIN:
- W1K2J5KBXNA096096

-$1,000
2022 Mercedes-Benz CLS
450 4MATIC
60,440 mi
$40,998
$39,998
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Black
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 45,145
- Stock #:
- MA084582P
- VIN:
- W1K2J5JB3MA084582

-$1,036
2021 Mercedes-Benz CLS
450 RWD
45,145 mi
$36,882
$35,846
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Blue
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Blue
- Transmission:
- 9-Speed Automatic
- Mileage:
- 32,169
- Stock #:
- 60120A
- VIN:
- W1K2J5KB8NA103658

2022 Mercedes-Benz CLS
450 4MATIC
32,169 mi
$47,374
About 2022 Mercedes-Benz CLS
- Year:
- 2023
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Polar White
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 16,435
- Stock #:
- BA118681
- VIN:
- W1K2J5KB8PA118681

2023 Mercedes-Benz CLS
450 4MATIC
16,435 mi
$57,990
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Selenite Gray Metallic
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 38,715
- Stock #:
- B10047P
- VIN:
- W1K2J5KBXNA105301

2022 Mercedes-Benz CLS
450 4MATIC
38,715 mi
$42,550
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- White
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Neva Gray/Magma Gray
- Transmission:
- 9-Speed Automatic
- Mileage:
- 19,940
- Stock #:
- 098678
- VIN:
- W1K2J5KB9NA098678

2022 Mercedes-Benz CLS
450 4MATIC
19,940 mi
$49,598
- Year:
- 2023
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Gray
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Transmission:
- Automatic
- Mileage:
- 11,894
- Stock #:
- NU526
- VIN:
- W1K2J5KBXPA113272

2023 Mercedes-Benz CLS
450 4MATIC
11,894 mi
$51,574
- Year:
- 2023
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Obsidian Black Metallic
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 7,408
- Stock #:
- F5743A
- VIN:
- W1K2J5KB1PA121342

2023 Mercedes-Benz CLS
450 4MATIC
7,408 mi
$55,698
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Black
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Transmission:
- 9-Speed Automatic
- Mileage:
- 40,442
- Stock #:
- UAC5346
- VIN:
- W1K2J5KB4NA101289

-$1,895
2022 Mercedes-Benz CLS
450 4MATIC
40,442 mi
$43,580
$41,685
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Polar White 149
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Java 214
- Transmission:
- Automatic
- Mileage:
- 46,591
- Stock #:
- P55556A
- VIN:
- W1K2J5KB4MA086260

2021 Mercedes-Benz CLS
450 4MATIC
46,591 mi
$35,654
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Polar White
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 28,623
- Stock #:
- 14437
- VIN:
- W1K2J5KB3NA100019

2022 Mercedes-Benz CLS
450 4MATIC
28,623 mi
$44,002
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Graphite Gray Metallic
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Sienna Brown/Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 45,448
- Stock #:
- NA105198
- VIN:
- W1K2J5KBXNA105198

2022 Mercedes-Benz CLS
450 4MATIC
45,448 mi
$41,821
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Graphite Gray Metallic
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 19,164
- Stock #:
- C261108A
- VIN:
- W1K2J5KB5MA087076

2021 Mercedes-Benz CLS
450 4MATIC
19,164 mi
$41,993
Overview

The Mercedes-Benz vehicles of today blend high-end luxury build quality with high performance and style. Heavy on the style part of that equation, the CLS gets an updated exterior, loses the rear-drive option, and can be outfitted inside with a larger number of leather-upholstery options for the 2022 model year.
The 2022 CLS450 gets a turbocharged 3.0-liter inline-six-cylinder engine equipped with a hybrid-assist system. The 48-volt EQ Boost feature helps the engine develop 362 horsepower and 369 pound-feet of torque. It also improves torque off the line and helps fill in gaps between transmission shifts. Speaking of which, every CLS comes with a nine-speed automatic transmission. Five driving modes are on offer to tailor drivetrain behavior and vehicle dynamics to various road conditions and driving situations.
The CLS features an exquisite interior with Nappa leather and a variety of metal and wood trim options. The car’s high style comes at the cost of interior space, however, as the CLS only manages 35 inches of legroom in the rear seat. The trunk also suffers, with just 12 cubic feet of space, just half of some of its rivals’ cargo areas.
Though it’s short on interior space, the CLS makes up points with its technology, which is impressive. The car comes with a 12.3-inch infotainment display and a 12.3-inch digital gauge cluster, both of which span halfway across the dash on a single large pane of glass. The latest version of Mercedes-Benz’s MBUX infotainment system runs here, as does Apple CarPlay and Android Auto. The system can be controlled via the touchscreen or through a center console-mounted touchpad. A head-up display (HUD) and wireless smartphone charging are available.
The CLS gets a few advanced driver aids as standard equipment, but many are added-cost options. Blind-spot monitoring, forward-collision warning, and automatic emergency braking are all standard. Features such as adaptive cruise control and lane-departure warning cost extra.
Mercedes hasn’t released pricing or sale information for the CLS yet, but the 2021 model started around $74,000. The 2022 model is expected to land close to that number when it goes on sale sometime early in calendar-year 2022.
3.0 Overall rating
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John S
Reviewed a 2022 Mercedes-Benz 450 4MATIC on Oct 15, 2025
It’s a little overpriced for a vehicle that is no longer in production
2022 Mercedes-Benz CLS Trims
| Trim type | MSRP |
|---|---|
| 450 4MATIC | $72,950 |
| AMG CLS 53 4MATIC | -- |
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