Used 2022 Mercedes-Benz S-Class S 500 4MATIC AWD for SaleNationwide
128 vehicles found
Shop with transparent pricing.
Only show listings that include dealer fees- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- White
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (Beige)
- Transmission:
- Automatic
- Mileage:
- 23,540
- Stock #:
- PM11832A
- VIN:
- W1K6G6DB6NA066516
Price drop
-$3,000
2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
23,540 mi
West Palm Beach, FL
Great Deal
$60,676
$57,676
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Gray
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 52,770
- Stock #:
- 92334
- VIN:
- W1K6G6DB8NA153284
New arrival
2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
52,770 mi
Lexington, SC
Fair Deal
$54,220
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- [049] MANUFAKTUR Cashmere White Magno Matte
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 47,584
- Stock #:
- M25104
- VIN:
- W1K6G6DB4NA105524
![[049] MANUFAKTUR Cashmere White Magno Matte 2022 Mercedes-Benz S-Class Sedan All-Wheel Drive Automatic](https://static.cargurus.com/images/forsale/2026/02/19/09/38/2022_mercedes-benz_s-class-pic-6989503168642358529-1024x768.jpeg?io=true&width=640&height=480&fit=bounds&format=jpg&auto=webp)
2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
47,584 mi
Dallas, TX
Good Deal
$54,224
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Gray
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 19,079
- Stock #:
- NA164518
- VIN:
- W1K6G6DB7NA164518
2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
19,079 mi
Marietta, GA
Good Deal
$60,198
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Gray (Graphite Grey)
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 69,208
- Stock #:
- NA122593
- VIN:
- W1K6G6DB9NA122593
Price drop
-$995
2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
69,208 mi
Pompano Beach, FL
Fair Deal
$48,990
$47,995
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Black
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 33,628
- Stock #:
- A158768
- VIN:
- W1K6G6DB0NA158768
2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
33,628 mi
West Palm Beach, FL
Great Deal
$53,995
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Black
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 49,145
- Stock #:
- CMTNA147090
- VIN:
- W1K6G6DB9NA147090
2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
49,145 mi
Orange City, FL
Fair Deal
$53,196
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- MANUFAKTUR Diamond White
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Sienna Brown/Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 46,293
- Stock #:
- PA10407
- VIN:
- W1K6G6DB2NA147450
2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
46,293 mi
Miami, FL
Good Deal
$55,935
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Black
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Macchiato/Magma Gray
- Transmission:
- 9-Speed Automatic
- Mileage:
- 16,294
- Stock #:
- NA069932A
- VIN:
- W1K6G6DB2NA069932
New arrival
2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
16,294 mi
San Antonio, TX
Good Deal
$61,787
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- White
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 30,489
- Stock #:
- I8151
- VIN:
- W1K6G6DB7NA128151
2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
30,489 mi
Fishers, IN
Great Deal
$52,249
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- White
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (Macchiato Beige/Magma Gray)
- Transmission:
- 9-Speed Automatic
- Mileage:
- 27,810
- Stock #:
- LE46885A
- VIN:
- W1K6G6DB3NA164399
2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
27,810 mi
Virginia Beach, VA
Fair Deal
$62,989
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Cirrus Silver Metallic
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 49,044
- Stock #:
- 11361
- VIN:
- W1K6G6DB9NA125932
2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
49,044 mi
Gulfport, MS
Fair Deal
$58,325
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Gray
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 67,631
- Stock #:
- NA131515
- VIN:
- W1K6G6DB1NA131515
2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
67,631 mi
Duluth, GA
Great Deal
$46,188
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Nautical Blue Metallic
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- PORCELAIN/ESPRESSO BROWN NAPPA LEATHER
- Transmission:
- 9-Speed Automatic
- Mileage:
- 10,783
- Stock #:
- U4452T
- VIN:
- W1K6G6DBXNA125549
2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
10,783 mi
Huntington, NY
Great Deal
$62,073
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Black - 040
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Gray (Macchiato/Magma Grey - 205)
- Transmission:
- 9-Speed Automatic
- Mileage:
- 66,200
- Stock #:
- 56311A
- VIN:
- W1K6G6DB0NA156311
2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
66,200 mi
Mt Ephraim, NJ
Fair Deal
$49,375
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Gray (Graphite)
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 21,704
- Stock #:
- AB7566X
- VIN:
- W1K6G6DB2NA136061
2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
21,704 mi
Dedham, MA
Great Deal
$58,395
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Gold
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Transmission:
- Automatic
- Mileage:
- 42,974
- Stock #:
- L1277A
- VIN:
- W1K6G6DB0NA065846
2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
42,974 mi
Golden Valley, MN
Great Deal
$52,846
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Black
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 46,656
- Stock #:
- NA164674
- VIN:
- W1K6G6DBXNA164674
2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
46,656 mi
Pompano Beach, FL
Good Deal
$54,991
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Black
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 25,167
- Stock #:
- J388131A
- VIN:
- W1K6G6DB6NA144695
New arrival
2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
25,167 mi
Clearwater, FL
Good Deal
$61,084
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Manufaktur Diamond White
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 54,876
- Stock #:
- 26305
- VIN:
- W1K6G6DB8NA166553
2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
54,876 mi
Santa Monica, CA
Great Deal
$48,897
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Kalahari Gold Metallic
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 40,322
- Stock #:
- A165625P
- VIN:
- W1K6G6DB2NA165625
2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
40,322 mi
Escondido, CA
Good Deal
$56,082
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Silver
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Transmission:
- Automatic
- Mileage:
- 25,832
- Stock #:
- NA078816
- VIN:
- W1K6G6DB1NA078816
2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
25,832 mi
Memphis, TN
Good Deal
$59,910
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Black
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 38,012
- Stock #:
- 11721
- VIN:
- W1K6G6DB9NA166593
2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
38,012 mi
Victorville, CA
Fair Deal
$56,938
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Black
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 36,066
- Stock #:
- ND3822
- VIN:
- W1K6G6DB9NA129270
2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
36,066 mi
Northbrook, IL
Fair Deal
$58,955
FAQs
How much does the Mercedes-Benz S-Class S 500 4MATIC AWD cost?
The average Mercedes-Benz S-Class S 500 4MATIC AWD costs about $63,429.75. The average price has decreased by -3.5% since last year. The 325 for sale on CarGurus range from $45,500 to $82,272 in price.
How many Mercedes-Benz S-Class S 500 4MATIC AWD vehicles have no reported accidents or damage?
286 out of 325 for sale have no reported accidents or damage.
What is the fuel economy of the Mercedes-Benz S-Class S 500 4MATIC AWD?
Depending on the engine and options, the Mercedes-Benz S-Class S 500 4MATIC AWD gets between 23 and 25 MPG/MPGe.
What fuel types are available?
Gasoline engines are available.
*CarGurus meticulously monitors the prices of millions of pre-owned vehicle listings, offering users precise and up-to-date market insights. Historical pricing data excludes any additional dealer fees as of May 3, 2026.
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