Used 2022 Mercedes-Benz S-Class S 580 4MATIC AWD for SaleNationwide
253 vehicles found
Shop with transparent pricing.
Only show listings that include dealer fees- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Cirrus Silver Metallic
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 67,280
- Stock #:
- P149494
- VIN:
- W1K6G7GB8NA149494
Price drop
-$1,589
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
67,280 mi
Macon, GA
Good Deal
$57,185
$55,596
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Nautical Blue Metallic
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (Macchiato Beige/Magma Gray)
- Transmission:
- 9-Speed Automatic
- Mileage:
- 61,808
- Stock #:
- ATN004793A
- VIN:
- W1K6G7GB9NA148693
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
61,808 mi
Duluth, GA
Great Deal
$52,173
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- MANUFAKTUR Kalahari Gold
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 26,898
- Stock #:
- NA091547
- VIN:
- W1K6G7GB8NA091547
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
26,898 mi
Tulsa, OK
Great Deal
$62,116
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Gray
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 31,770
- Stock #:
- M913541
- VIN:
- W1K6G7GB6NA163362
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
31,770 mi
Pompano Beach, FL
Good Deal
$69,696
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 41,967
- Stock #:
- T1037
- VIN:
- W1K6G7GBXNA138061
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
41,967 mi
Sunbury, OH
Good Deal
$65,442
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 26,573
- Stock #:
- 10619-TR
- VIN:
- W1K6G7GB6NA128241
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
26,573 mi
Joliet, IL
Good Deal
$67,353
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- MANUFAKTUR Diamond White
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Silver Grey/Black
- Transmission:
- Automatic
- Mileage:
- 33,001
- Stock #:
- 25W3617A
- VIN:
- W1K6G7GB4NA139710
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
33,001 mi
Harvey, LA
Good Deal
$66,400
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Silver
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 26,908
- Stock #:
- NA069419STK
- VIN:
- W1K6G7GBXNA069419
New arrival
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
26,908 mi
Dallas, TX
Good Deal
$68,917
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Red
- Transmission:
- 9-Speed Automatic
- Mileage:
- 40,975
- Stock #:
- 2P5560
- VIN:
- W1K6G7GB5NA091697
Price drop
-$2,495
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
40,975 mi
Virginia Beach, VA
Fair Deal
$68,495
$66,995
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 47,399
- Stock #:
- NA079649A
- VIN:
- W1K6G7GB0NA079649
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
47,399 mi
Marietta, GA
Great Deal
$58,243
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- MANUFAKTUR Diamond White
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (Macchiato Beige/Magma Gray)
- Transmission:
- 9-Speed Automatic
- Mileage:
- 20,054
- Stock #:
- UM8185A
- VIN:
- W1K6G7GB9NA072313
New arrival
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
20,054 mi
Westmont, IL
Fair Deal
$72,358
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 19,521
- Stock #:
- 148212
- VIN:
- W1K6G7GB0NA148212
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
19,521 mi
Tempe, AZ
Good Deal
$70,387
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Silver Grey/Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 10,263
- Stock #:
- 12743Z
- VIN:
- W1K6G7GB6NA137280
New arrival
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
10,263 mi
Bellevue, WA
Fair Deal
$81,977
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- White
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Transmission:
- 9-Speed Automatic
- Mileage:
- 65,448
- Stock #:
- 072602
- VIN:
- W1K6G7GB5NA072602
Price drop
-$2,878
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
65,448 mi
Mokena, IL
Fair Deal
$58,288
$55,411
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Red
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 35,668
- Stock #:
- NA071362
- VIN:
- W1K6G7GB6NA071362
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
35,668 mi
Duluth, GA
Good Deal
$62,188
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Transmission:
- 9-Speed Automatic
- Mileage:
- 25,250
- Stock #:
- 096873
- VIN:
- W1K6G7GB2NA096873
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
25,250 mi
Pawtucket, RI
Fair Deal
$73,846
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- MANUFAKTUR Diamond White
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Sienna Brown/Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 10,137
- Stock #:
- BNA068744
- VIN:
- W1K6G7GB5NA068744
New arrival
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
10,137 mi
Plano, TX
Good Deal
$74,225
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Graphite Gray Metallic
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Sienna Brown/Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 18,099
- Stock #:
- PL00772
- VIN:
- W1K6G7GB3NA121571
New arrival
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
18,099 mi
Laguna Niguel, CA
Good Deal
$69,976
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Blue
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Exclusive Silver Gray/Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 76,546
- Stock #:
- TNA080141H
- VIN:
- W1K6G7GB2NA080141
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
76,546 mi
Clarksville, TN
Great Deal
$49,795
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Gray
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (Beige)
- Transmission:
- 9-Speed Automatic
- Mileage:
- 34,087
- Stock #:
- U40362
- VIN:
- W1K6G7GB6NA157173
Price drop
-$2,130
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
34,087 mi
Alpharetta, GA
Fair Deal
$70,598
$68,468
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Cirrus Silver
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Silver Grey/Black
- Transmission:
- Automatic
- Mileage:
- 37,566
- Stock #:
- P1156
- VIN:
- W1K6G7GB8NA149883
New arrival
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
37,566 mi
Henderson, NV
Fair Deal
$70,989
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- White
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Exclusive Carmine Red/Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 62,762
- Stock #:
- NA118840A
- VIN:
- W1K6G7GB0NA118840
Price drop
-$4,095
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
62,762 mi
Conyers, GA
Great Deal
$56,788
$52,693
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (Macchiato Beige / Magma Grey E)
- Transmission:
- 9-Speed Automatic
- Mileage:
- 34,516
- Stock #:
- M6050A
- VIN:
- W1K6G7GB2NA113283
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
34,516 mi
Columbia, MO
Good Deal
$65,279
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Transmission:
- 9-Speed Automatic
- Mileage:
- 26,005
- Stock #:
- NA118510
- VIN:
- W1K6G7GB1NA118510
New arrival
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
26,005 mi
Alpharetta, GA
Good Deal
$66,096
FAQs
How much does the Mercedes-Benz S-Class S 580 4MATIC AWD cost?
The average Mercedes-Benz S-Class S 580 4MATIC AWD costs about $63,694.70. The average price has decreased by -3.2% since last year. The 543 for sale on CarGurus range from $46,450 to $105,674 in price.
How many Mercedes-Benz S-Class S 580 4MATIC AWD vehicles have no reported accidents or damage?
473 out of 543 for sale have no reported accidents or damage.
What is the fuel economy of the Mercedes-Benz S-Class S 580 4MATIC AWD?
Depending on the engine and options, the Mercedes-Benz S-Class S 580 4MATIC AWD gets between 20 and 20 MPG/MPGe.
What fuel types are available?
Gasoline engines are available.
*CarGurus meticulously monitors the prices of millions of pre-owned vehicle listings, offering users precise and up-to-date market insights. Historical pricing data excludes any additional dealer fees as of May 3, 2026.
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