2021 Lexus RX vs 2022 Toyota Sequoia
Overview | |
MSRP$45,220 | MSRP$50,500 |
Listings80 | Listings36 |
Ratings & Reviews | |
User Reviews | User Reviews |
Expert reviews7.8 out of 10 | Expert reviews7.3 out of 10 |
Pros
Cons
| Pros
Cons
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2021 Lexus RX Reviews SummaryThe body and mechanics of the midsize Lexus RX are mostly unchanged for the 2021 model year. It remains a formidable luxury SUV with comfortable accommodations and plenty of creature comforts. Lexus’ tradition of reliability extends to the RX as well. There are a few tech upgrades worth noting for 2021, including new standard safety systems. | |
2022 Toyota Sequoia Reviews SummaryThe 2022 Toyota Sequoia shares its platform with the Toyota Tundra pickup truck. It comes with rear-wheel-drive (RWD) or available four-wheel-drive (4WD) drivetrains, except TRD Pro models, which come with standard 4WD. The Sequoia and comes in six trim levels: SR5, TRD Sport, TRD Pro, Limited, Platinum, and the Nightshade Special Edition. While competitors have refreshed their full-size SUVs over the past few years, Toyota has stood pat with the Sequoia, relying on minor cosmetic updates to keep the SUV in the hunt since 2008. | |
No video found | No video found |
Popular Features & Specs | |
Engine3.5L 295 hp V6 | Engine5.7L 381 hp V8 |
Drive TrainFWD | Drive Train4X2 |
Seating Capacity5 | Seating Capacity8 |
Horsepower295 hp @ 6300 rpm | Horsepower381 hp @ 5600 rpm |
MPG City20 | MPG City13 |
MPG Highway27 | MPG Highway17 |
Engine | |
Engine Name3.5L 295 hp V6 | Engine Name5.7L 381 hp V8 |
Torque267 lb-ft @ 4700 rpm | Torque401 lb-ft @ 3600 rpm |
Horsepower295 hp @ 6300 rpm | Horsepower381 hp @ 5600 rpm |
DrivetrainFWD | Drivetrain4X2 |
Fuel Economy | |
MPG City20 | MPG City13 |
MPG Highway27 | MPG Highway17 |
Interior | |
Seating Capacity5 | Seating Capacity8 |
Key Features | |
Sunroof/Moonroof | Sunroof/MoonroofStandard |
Safety | |
Front Crash Overall4 | Front Crash Overall |
Side Crash Overall5 | Side Crash Overall |
Dimensions & Capacity | |
Cargo Space16.0 cu ft | Cargo Space18.9 cu ft |
Curb Weight4222 lbs | Curb Weight5730 lbs |
Height67.7 in | Height77.0 in |
Length192.5 in | Length205.1 in |
Width74.6 in | Width79.9 in |
Wheelbase109.8 in | Wheelbase122.0 in |
Maximum Payload920 lbs | Maximum Payload1405 lbs |
Number of doors4 | Number of doors4 |
Maximum Towing Capacity3500 lbs | Maximum Towing Capacity7400 lbs |
Standard Towing Capacity | Standard Towing Capacity7400 lbs |
Overview | ||
MSRP | $45,220 | $50,500 |
Listings | ||
Ratings & Reviews | ||
User reviews | ||
Expert reviews | 7.8 out of 10Read full review | 7.3 out of 10Read full review |
Pros & cons | Pros
Cons
| Pros
Cons
|
Summary | The body and mechanics of the midsize Lexus RX are mostly unchanged for the 2021 model year. It remains a formidable luxury SUV with comfortable accommodations and plenty of creature comforts. Lexus’ tradition of reliability extends to the RX as well. There are a few tech upgrades worth noting for 2021, including new standard safety systems. | The 2022 Toyota Sequoia shares its platform with the Toyota Tundra pickup truck. It comes with rear-wheel-drive (RWD) or available four-wheel-drive (4WD) drivetrains, except TRD Pro models, which come with standard 4WD. The Sequoia and comes in six trim levels: SR5, TRD Sport, TRD Pro, Limited, Platinum, and the Nightshade Special Edition. While competitors have refreshed their full-size SUVs over the past few years, Toyota has stood pat with the Sequoia, relying on minor cosmetic updates to keep the SUV in the hunt since 2008. |
Video | No video found | No video found |
Popular Features & Specs | ||
Engine | 3.5L 295 hp V6 | 5.7L 381 hp V8 |
Drive Train | FWD | 4X2 |
Seating Capacity | 5 | 8 |
Horsepower | 295 hp @ 6300 rpm | 381 hp @ 5600 rpm |
MPG City | 20 | 13 |
MPG Highway | 27 | 17 |
Engine | ||
Engine Name | 3.5L 295 hp V6 | 5.7L 381 hp V8 |
Torque | 267 lb-ft @ 4700 rpm | 401 lb-ft @ 3600 rpm |
Horsepower | 295 hp @ 6300 rpm | 381 hp @ 5600 rpm |
Drivetrain | FWD | 4X2 |
Fuel Economy | ||
MPG City | 20 | 13 |
MPG Highway | 27 | 17 |
Interior | ||
Seating Capacity | 5 | 8 |
Key Features | ||
Sunroof/Moonroof | Standard | |
Safety | ||
Front Crash Overall | 4 | |
Side Crash Overall | 5 | |
Dimensions & Capacity | ||
Cargo Space | 16.0 cu ft | 18.9 cu ft |
Curb Weight | 4222 lbs | 5730 lbs |
Height | 67.7 in | 77.0 in |
Length | 192.5 in | 205.1 in |
Width | 74.6 in | 79.9 in |
Wheelbase | 109.8 in | 122.0 in |
Maximum Payload | 920 lbs | 1405 lbs |
Number of doors | 4 | 4 |
Maximum Towing Capacity | 3500 lbs | 7400 lbs |
Standard Towing Capacity | 7400 lbs | |
The 2021 Lexus RX showcased a modern design aesthetic that was emblematic of the brand's styling ethos. It featured a large grille, angular headlamps, and a shapely body with a floating roof. The interior was luxurious, with sumptuous seating and perforated leather upholstery, although the center console was criticized for its dated appearance. The RX was available in five variants, including the performance-focused RX F Sport and the extended-body RXL models with a third row of seating. Standard features included 18-inch aluminum wheels, LED lighting, and rear privacy glass, with options for larger wheels and additional exterior upgrades. The interior offered a range of amenities, from power-adjustable front seats to semi-aniline leather upholstery and heated steering wheels, though the infotainment system was noted for its functional yet outdated design.
The 2022 Toyota Sequoia, on the other hand, continued its second generation into its 14th year, maintaining a mature design. Its exterior was characterized by a modestly sized grille, elegant wheel arches, and straight body lines, giving it a substantial presence. The Sequoia's interior, while well-constructed with high-quality materials, appeared dated compared to more modern SUVs. The 7-inch touchscreen and 4.5-inch driver information screen were seen as relics from a previous era. However, the Sequoia's interior was spacious and durable, designed to withstand the demands of a growing family. The Nightshade Special Edition added a contemporary touch with darkened chrome and black-painted finishes, enhancing its visual appeal.














The 2021 Lexus RX was powered by a 3.5-liter V6 engine, delivering 295 horsepower and 267 pound-feet of torque, paired with an eight-speed automatic transmission. The RX Hybrid models offered 308 horsepower with a 3.5-liter V6 and three electric motors, managed by an electronic continuously variable transmission (e-CVT). The RX was praised for its comfortable cruising capabilities, with the F Sport model providing a more spirited driving experience. Fuel efficiency varied, with the FWD RX 350 achieving 20 mpg city and 27 mpg highway, while the RX Hybrid models managed up to 31 mpg city. The RX's handling was improved with tuning adjustments, offering a dynamic driving experience, though some body roll was noted at higher speeds.
In contrast, the 2022 Toyota Sequoia was equipped with a 5.7-liter i-Force V8 engine, producing 381 horsepower and 401 pound-feet of torque, paired with a six-speed automatic transmission. The Sequoia's truck-based roots contributed to its impressive payload capacity of around 1,300 pounds and a towing capacity of 7,400 pounds. However, its fuel economy was less favorable, with ratings of 13 mpg city and 17 mpg highway for both RWD and 4WD models. Despite its weight, the Sequoia offered a smooth and stable ride, with competent off-road capabilities thanks to its robust construction and ample ground clearance. The TRD Pro model further enhanced its off-road prowess with specialized suspension tuning.
The 2021 Lexus RX offered a functional interior with seating for five in the two-row models and up to seven in the three-row RXL versions. Front and second-row seating provided ample space, though the third row was tight. Cargo space was limited compared to traditional SUVs, with 18.4 cubic feet behind the second row and 56.3 cubic feet with seats folded in the two-row models. The three-row RXL offered 7.5 cubic feet behind the third row and up to 58.5 cubic feet with seats folded. A power liftgate was standard, with a hands-free option available.
The 2022 Toyota Sequoia prioritized passenger comfort with spacious seating across all three rows and three-zone climate control. The cargo area offered 18.9 cubic feet behind the third row, expanding to 66.6 cubic feet with the third row folded, and a generous 120.1 cubic feet with both rear rows down. The Sequoia's interior featured ample storage options, including a large center console and door pockets, while a 12-volt outlet in the cargo area added convenience for outdoor activities.
The 2021 Lexus RX came equipped with dual-zone automatic climate control, an 8-inch infotainment touchscreen, and connectivity features like Apple CarPlay, Android Auto, and Amazon Alexa. Upgrades included a 12.3-inch touchscreen, wireless charging, and a premium Mark Levinson sound system. The infotainment system, while functional, was criticized for its complexity and lack of wireless smartphone integration.
The 2022 Toyota Sequoia's technology was seen as outdated, with a 7-inch touchscreen and a 4.5-inch driver information screen. However, it offered standard Apple CarPlay and Android Auto, along with WiFi connectivity and SiriusXM satellite radio. The Limited trim added navigation and a 12-speaker audio system, while a premium package included a JBL sound system. Despite its dated infotainment, the Sequoia featured modern LED lighting and safety technologies like a rear backup camera and parking sonar.
The 2021 Lexus RX received a Top Safety Pick designation from the IIHS, with Good marks in crashworthiness tests. The NHTSA awarded it four out of five stars overall, with a perfect score for side-impact crashworthiness. Standard safety features included 10 airbags, blind-spot monitoring, and the Lexus Safety System+ 2.0 suite, which offered a range of driver-assist technologies. However, it lacked the advanced hands-off piloting features found in some competitors.
The 2022 Toyota Sequoia had not been rated by the NHTSA or IIHS, but it offered a comprehensive suite of safety features. The Toyota Safety Sense P (TSS-P) included a pre-collision system with pedestrian detection, adaptive cruise control, and lane-departure alert. The STAR safety system provided stability control, traction control, and anti-lock brakes. The Sequoia also featured a full complement of airbags, LATCH connectors, and energy-absorbing crumple zones, along with parking-assist sonar and child-protector rear door locks.
CarGurus highlights

According to CarGurus experts, the overall rating for the 2021 Lexus RX is 7.8 out of 10, while the 2022 Toyota Sequoia scores 7.3 out of 10. Based on these ratings, the 2021 Lexus RX is the recommended choice, offering a more modern design, better fuel efficiency, and advanced safety features.
Choose the 2021 Lexus RX if:
- You prioritize a modern design with luxurious interior features and a comfortable ride.
- Fuel efficiency and hybrid options are important to you.
- You value advanced safety ratings and a comprehensive suite of driver-assist technologies.
Choose the 2022 Toyota Sequoia if:
- You need a spacious and durable SUV with ample passenger and cargo space.
- Towing capacity and off-road capabilities are essential for your lifestyle.
- You prefer a vehicle with a proven track record of reliability and durability.
CarGurus highlights

According to CarGurus experts, the overall rating for the 2021 Lexus RX is 7.8 out of 10, while the 2022 Toyota Sequoia scores 7.3 out of 10. Based on these ratings, the 2021 Lexus RX is the recommended choice, offering a more modern design, better fuel efficiency, and advanced safety features.
Choose the 2021 Lexus RX if:
Shop Now- You prioritize a modern design with luxurious interior features and a comfortable ride.
- Fuel efficiency and hybrid options are important to you.
- You value advanced safety ratings and a comprehensive suite of driver-assist technologies.
Choose the 2022 Toyota Sequoia if:
Shop Now- You need a spacious and durable SUV with ample passenger and cargo space.
- Towing capacity and off-road capabilities are essential for your lifestyle.
- You prefer a vehicle with a proven track record of reliability and durability.

By: CarGurus + AI
At CarGurus, our team of experienced automotive writers remain at the heart of our content operation, conducting hands-on car tests and writing insightful guides that are backed by years of industry experience. To complement this, we are harnessing AI to make our content offering more diverse and more helpful to shoppers than ever. To achieve this, our AI systems are based exclusively on CarGurus content, ratings and data, so that what we produce is both unique to CarGurus, and uniquely helpful to car shoppers.







































